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uterine contraction

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35

Inhibitors & Agonists

1

Biochemical Assay Reagents

6

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6070
    Ricinoleic acid (purity≥85%)

    		Environmental Pollutants Prostaglandin Receptor Inflammation/Immunology
    Ricinoleic acid (purity≥85%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
    Ricinoleic acid (purity≥85%)
  • HY-103192
    MDL12330A
    5 Publications Verification

    RMI12330A

    		 Adenylate Cyclase Potassium Channel Neurological Disease Cancer
    MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca 2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
    MDL12330A
  • HY-N6070A
    Ricinoleic acid (purity≥99%)

    		Environmental Pollutants Prostaglandin Receptor Inflammation/Immunology
    Ricinoleic acid (purity≥99%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
    Ricinoleic acid (purity≥99%)
  • HY-P2168
    Demoxytocin

    		Oxytocin Receptor Drug Derivative Metabolic Disease
    Demoxytocin is a heterologous cyclic peptide and an analog of Oxytocin (HY-17571). Demoxytocin affects the permeability of cell membranes and increases calcium ion levels in smooth muscle cells, thereby enhancing the contraction of smooth muscle cells. Demoxytocin also stimulates the contraction of uterine smooth muscle. Demoxytocin possesses the functions of oxytocin. Demoxytocin can be used to study labor stimulation in preterm premature rupture of membranes .
    Demoxytocin
  • HY-108974
    Drotaverine hydrochloride

    		Phosphodiesterase (PDE) Calcium Channel Neurological Disease
    Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride
  • HY-B0452
    Ritodrine hydrochloride
    2 Publications Verification

    DU21220 hydrochloride

    		 Adrenergic Receptor Endocrinology
    Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor .
    Ritodrine hydrochloride
  • HY-128428
    Carboprost

    15(S)-15-Methyl Prostaglandin F2α; 15-Methyl-PGF2α

    		 Prostaglandin Receptor Endocrinology
    Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
    Carboprost
  • HY-14778
    Retosiban

    GSK 221149; GSK 221149A

    		 Oxytocin Receptor Neurological Disease Endocrinology
    Retosiban (GSK221149A) is a potent, selective, and orally active oxytocin receptor antagonist (Ki (hOT) = 0.65 nM, Ki (rOT) = 4.1 nM) with no detectable agonist activity. Retosiban has nanomolar affinity for the oxytocin receptor with >1400-fold selectivity over the closely related vasopressin receptors. Retosiban inhibits spontaneous and induces uterine contractions. Retosiban can be studied in research for preterm labour .
    Retosiban
  • HY-P3217A
    [Asp5]-Oxytocin acetate

    		Oxytocin Receptor Endocrinology
    [Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
    [Asp5]-Oxytocin acetate
  • HY-P4160
    PDC31

    THG113.31; ILGHXDYK

    		 Prostaglandin Receptor Endocrinology
    PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca 2+-dependent large-conductance K +-channel in human myometrial cells .
    PDC31
  • HY-15008
    L-368,899

    		Oxytocin Receptor Endocrinology
    L-368,899 is an orally active and selective OT (oxytocin ) receptor antagonist, with IC50s of 8.9 and 26 nM for uterus of rat and human, respectively. L-368,899 can cross the blood-brain barrier (BBB). L-368,899 inhibits oxytocin-stimulated uterine contractions in rats and can be used in study of preterm labor .
    L-368,899
  • HY-103283
    Neuromedin C (porcine)

    GRP(18-27) (porcine)

    		 Biochemical Assay Reagents Neurological Disease
    Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .
    Neuromedin C (porcine)
  • HY-135447
    BM-531

    		Prostaglandin Receptor Others
    BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K +-induced contraction of porcine uterine smooth muscle .
    BM-531
  • HY-129791
    L-367773

    		Oxytocin Receptor Endocrinology
    L-367773 is an orally active, selective oxytocin receptor antagonist, with Ki values of 26 nM and 61 nM for rat uterine oxytocin receptor and human uterine oxytocin receptor, respectively. L-367773 inhibits Oxytocin-stimulated uterine contractions .
    L-367773
  • HY-16741
    Erlosiban

    OBE001

    		 Oxytocin Receptor Endocrinology
    Erlosiban (OBE001) is an orally active non-peptide type oxytocin receptor antagonist. Erlosiban inhibits the increase of intracellular calcium concentration, thereby reducing uterine smooth muscle contraction. Erlosiban can be used for research on premature birth and to improve embryo implantation and pregnancy rate in assisted reproductive technology (AR).
    Erlosiban
  • HY-P3217
    [Asp5]-Oxytocin

    		Oxytocin Receptor Endocrinology
    [Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg 2+. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .
    [Asp5]-Oxytocin
  • HY-P2034
    Cargutocin

    		Oxytocin Receptor Endocrinology
    Cargutocin, an oxytocin analogue, targets the oxytocin receptor and acts as a uterine contraction agent .
    Cargutocin
  • HY-W414644
    Fluacrypyrim

    		Parasite STAT Phosphatase MDM-2/p53 Apoptosis Infection Neurological Disease Inflammation/Immunology Cancer
    Fluacrypyrim, a Miticide, is a STAT3 inhibitor. Fluacrypyrim significantly increases the protein tyrosine phosphatases(PTPs) activity. Fluacrypyrim inhibits the growth of leukemia cells by a predominant G1 arrest with significant decrease of the protein and mRNA levels of cyclin D1. Fluacrypyrim selectively inhibits STAT3 signaling, inducing growth arrest and apoptosis in STAT3-dependent cancer cells. Fluacrypyrim mitigates IR-induced hematopoietic system injury mainly by preventing apoptosis in the HSCs. Fluacrypyrim demonstrates significant analgesic and anti-inflammatory effects by inhibiting uterine smooth muscle contraction and inflammatory responses .
    Fluacrypyrim
  • HY-157495
    EP3 antagonist 6

    		Prostaglandin Receptor Endocrinology
    EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC50 of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats .
    EP3 antagonist 6
  • HY-B0452A
    Ritodrine

    DU21220

    		 Adrenergic Receptor Endocrinology
    Ritodrine (DU21220) is a β-adrenergic agonist, also an effective smooth muscle and uterine relaxant. Ritodrine prolongs contraction interval, can be used for researching arrest premature labor .
    Ritodrine
  • HY-B0452R
    Ritodrine hydrochloride (Standard)

    DU21220 hydrochloride (Standard)

    		 Reference Standards Adrenergic Receptor Endocrinology
    Ritodrine (hydrochloride) (Standard) is the analytical standard of Ritodrine (hydrochloride). This product is intended for research and analytical applications. Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor .
    Ritodrine hydrochloride (Standard)
  • HY-128428R
    Carboprost (Standard)

    15(S)-15-Methyl Prostaglandin F2α (Standard); 15-Methyl-PGF2α (Standard)

    		 Reference Standards Prostaglandin Receptor Endocrinology
    Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
    Carboprost (Standard)
  • HY-120506
    L-366811

    		Bradykinin Receptor Others
    L-366811 is a compound with bradykinin agonist activity, with activity to stimulate phosphatidylinositol turnover and induce uterine contraction. L-366811 stimulates phosphatidylinositol turnover in rat uterine slices and induces rat uterine contraction in vitro, with moderate affinity for the [3H]BK binding site.
    L-366811
  • HY-106077
    Meteneprost

    U 46785

    		 Prostaglandin Receptor Others
    Meteneprost (U 46785) is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.
    Meteneprost
  • HY-106077A
    Meteneprost potassium

    U 46785 potassium

    		 Prostaglandin Receptor Others
    Meteneprost (U 46785) potassium is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.
    Meteneprost potassium
  • HY-111225
    VA-111913

    VT-913

    		 Vasopressin Receptor Cardiovascular Disease Neurological Disease
    VA-111913 (VT-913) is a vasopressin receptor V1A antagonist (Ki = 1.74 nM). VA-111913 reduces uterine contractions and improves uterine blood flow by inhibiting vasopressin, thereby alleviating dysmenorrhea. VA-111913 can be used for research on menstrual pain .
    VA-111913
  • HY-15018A
    SSR126768A free base

    		Oxytocin Receptor Endocrinology
    SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca 2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor .
    SSR126768A free base
  • HY-131696
    11-deoxy Prostaglandin F1α

    11-deoxy PGF1α

    		 Prostaglandin Receptor Cardiovascular Disease Others
    11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor .
    11-deoxy Prostaglandin F1α
  • HY-108974R
    Drotaverine hydrochloride (Standard)

    		Phosphodiesterase (PDE) Calcium Channel Reference Standards Neurological Disease
    Drotaverine (hydrochloride) (Standard) is the analytical standard of Drotaverine (hydrochloride). This product is intended for research and analytical applications. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride (Standard)
  • HY-A0252A
    Bupranolol hydrochloride

    		Adrenergic Receptor Cancer
    Bupranolol hydrochloride is a non-selective β-adrenergic blocker with potent membrane stabilizing activity. Bupranolol hydrochloride is able to significantly modulate the contractile activity of the non-pregnant human uterus. Bupranolol hydrochloride showed significant effects on spontaneous uterine contractions in an in vitro study in patients with ovarian cancer. Bupranolol hydrochloride is similar in potency to propranolol, another β-adrenergic blocker. Bupranolol hydrochloride is rapidly and completely absorbed in vivo, and its major metabolite is carboxybupranolol .
    Bupranolol hydrochloride
  • HY-N6070AR
    Ricinoleic acid (Standard)

    		Reference Standards Prostaglandin Receptor Inflammation/Immunology
    Ricinoleic acid (Standard) is the analytical standard of Ricinoleic acid. This product is intended for research and analytical applications. Ricinoleic acid, a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
    Ricinoleic acid (Standard)
  • HY-15007
    L 366509

    		Oxytocin Receptor Endocrinology
    L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists .
    L 366509
  • HY-181443
    15(S)-15-Methyl Prostaglandin F2α ethyl amide

    		Drug Derivative Prostaglandin Receptor Endocrinology
    15(S)-15-Methyl Prostaglandin F2α ethyl amide (15-Methyl Prostaglandin F2α ethyl amide) is a synthetic Prostaglandin F2α (HY-12956) analogue that stimulates uterine contractions. 15(S)-15-Methyl Prostaglandin F2α ethyl amide can be used for the research of second-trimester pregnancy loss .
    15(S)-15-Methyl Prostaglandin F2α ethyl amide
  • HY-103192R
    MDL12330A (Standard)

    RMI12330A (Standard)

    		 Adenylate Cyclase Reference Standards Potassium Channel Neurological Disease Cancer
    MDL12330A (Standard) is the analytical standard of MDL12330A (HY-103192). MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca 2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
    MDL12330A (Standard)
  • HY-165456
    AGN-190851

    		Adrenergic Receptor Vasopressin Receptor Endocrinology
    AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition .
    AGN-190851

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