284464-46-6
Chemical Structure
BM-531
- CAS No.: 284464-46-6
- Formula:C17H26N4O5S
- Molecular Weight:398.48
IUPAC Name: N-(tert-butylcarbamoyl)-2-(cyclohexylamino)-5-nitrobenzenesulfonamide
InChIKey: LBAPYVMLNHDSLS-UHFFFAOYSA-N
SMILES: O=S(C1=CC([N+]([O-])=O)=CC=C1NC2CCCCC2)(NC(NC(C)(C)C)=O)=O
Biological Activity: BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K+-induced contraction of porcine uterine smooth muscle[1][2][3].
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BM-531 | BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K+-induced contraction of porcine uterine smooth muscle. | |||||||||||||||||||||
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- [1]. Dogné JM, et al. Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function. Prostaglandins Leukot Essent Fatty Acids. 2000 May;62(5):311-7. [Content Brief]
- [2]. Cao J, et al. Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur J Pharmacol. 2004 Feb 6;485(1-3):317-27. [Content Brief]
- [3]. Michaux C, et al. N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition. Acta Crystallogr C. 2002 Oct;58(Pt 10):o621-3. [Content Brief]
Keywords
