1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Ritodrine hydrochloride

Ritodrine hydrochloride (Synonyms: DU21220 hydrochloride)

Cat. No.: HY-B0452 Purity: 99.90%
Handling Instructions

Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.

For research use only. We do not sell to patients.

Ritodrine hydrochloride Chemical Structure

Ritodrine hydrochloride Chemical Structure

CAS No. : 23239-51-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ritodrine hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist. Target: β-2 Adrenergic Receptor Ritodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4'-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4'-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2].

Clinical Trial
Molecular Weight

323.81

Formula

C₁₇H₂₂ClNO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (370.59 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (308.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0882 mL 15.4412 mL 30.8823 mL
5 mM 0.6176 mL 3.0882 mL 6.1765 mL
10 mM 0.3088 mL 1.5441 mL 3.0882 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.71 mg/mL (5.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.71 mg/mL (5.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.71 mg/mL (5.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Ritodrine hydrochloride
Cat. No.:
HY-B0452
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