2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. PDC31

PDC31  (Synonyms: THG113.31; ILGHXDYK)

Cat. No.: HY-P4160 Purity: 99.76%
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PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large-conductance K+-channel in human myometrial cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PDC31 Chemical Structure

PDC31 Chemical Structure

CAS No. : 634586-40-6

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5 mg USD 140 In-stock
10 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

PDC31 Related Antibodies

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Description

PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large-conductance K+-channel in human myometrial cells[1][2].

IC50 & Target[1]

FP Receptor

~30 nM (Ki)

PGF2α

 

In Vitro

PDC31 (10 μM, 50 μM; ) stimulates the BKCa channel in human myometrial smooth muscle cells, and enhances open state channel activity with average 4 and 6-fold by 10 and 50 μM, respectively[2].
PDC31 (1 nM-10 μM; 20 min intervals) cumulatively inhibits spontaneous contractions in isolated pregnant human myometrium[2].
PDC31 consists of ILGHXDYK, associated sequence is based on a transmembrane domain of the human PGF2a receptor[3]. PDC31 has been shown to reduce the duration and strength of PGF2a-induced contractions in myometrial strip models and to delay delivery in animal models of preterm labor[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDC31 Related Antibodies
Clinical Trial
Molecular Weight

1002.12

Formula

C45H71N13O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

d-(Ile-Leu-Gly-His-Cit-Asp-Tyr-Lys)
Sequence Shortening

d-(ILGHXDYK)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (99.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9979 mL 4.9894 mL 9.9788 mL
5 mM 0.1996 mL 0.9979 mL 1.9958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9979 mL 4.9894 mL 9.9788 mL 24.9471 mL
5 mM 0.1996 mL 0.9979 mL 1.9958 mL 4.9894 mL
10 mM 0.0998 mL 0.4989 mL 0.9979 mL 2.4947 mL
15 mM 0.0665 mL 0.3326 mL 0.6653 mL 1.6631 mL
20 mM 0.0499 mL 0.2495 mL 0.4989 mL 1.2474 mL
25 mM 0.0399 mL 0.1996 mL 0.3992 mL 0.9979 mL
30 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8316 mL
40 mM 0.0249 mL 0.1247 mL 0.2495 mL 0.6237 mL
50 mM 0.0200 mL 0.0998 mL 0.1996 mL 0.4989 mL
60 mM 0.0166 mL 0.0832 mL 0.1663 mL 0.4158 mL
80 mM 0.0125 mL 0.0624 mL 0.1247 mL 0.3118 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PDC31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDC31634586-40-6THG113.31 ILGHXDYKPDC 31PDC-31Prostaglandin ReceptorInhibitorinhibitorinhibit

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