15 Results for "

viral pneumonia

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "viral pneumonia" in MCE Product Catalog:

39
39 Publications Verification
Cat. No.: HY-100442
CAS No.: 248282-01-1
Purity:  99.90%
Synonyms: ABR-215757; ABR 25757
Target:  

SARS-CoV

Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
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3 Cited Publications
Cat. No.: HY-126085
CAS No.: 17795-26-5
Purity:  98.21%
Synonyms: (±)-L-Alliin
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .
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1 Cited Publications
Cat. No.: HY-N0677A
CAS No.: 76958-99-1
Synonyms: Potassium dehydroandrographolide succinate
Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate) is an antibiotic. Kalii Dehydrographolidi Succinas exerts immunostimulatory, anti-infective and anti-inflammatory effects . Kalii Dehydrographolidi Succinas shows potential for research on viral pneumonia and viral upper respiratory tract infections .
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1 Cited Publications
Cat. No.: HY-N0677
CAS No.: 786593-06-4
Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways .
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Cat. No.: HY-155876
CAS No.: 2271394-34-2
Purity:  99.97%
Synonyms: NLRP3 antagonist 2
NVP-DFV890 is an orally administered, selective NLRP3 inhibitor. NVP-DFV890 directly binds to NLRP3, blocks maturation of pro-inflammatory cytokines IL-1β and IL-18, and inhibits pyroptotic cell death. NVP-DFV890 acts as an inducer of viral clearance, promoting earlier clearance of SARS-CoV-2. NVP-DFV890 can be used for the research of COVID-19 pneumonia and coronavirus-associated acute respiratory distress syndrome (CARDS) .
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Cat. No.: HY-P990094
CAS No.: 2643974-98-3
Synonyms: CSL311

Target:  

c-Fms

Research Areas:  

Inflammation/Immunology

Trabikibart (CSL311) is a specific inhibitor targeting the βc receptor (CSF2RB) that inhibits signal transduction mediated by GM-CSF, IL-5, and IL-3. Trabikibart exhibits significant anti-inflammatory and anti-edema effects, reduces myeloid cell infiltration, and inhibits inflammatory cell survival. Trabikibart also possesses antiviral immune functions, which alleviate pulmonary inflammation, reverse airway dysfunction and fibrosis, and thereby restore impaired pulmonary function. Trabikibart can be used in research on related diseases such as acute respiratory distress syndrome, viral pneumonia, asthma, and chronic rhinosinusitis with nasal polyps .
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Cat. No.: HY-177119
Research Areas:  

Infection

ZBP1 Covalent PROTAC-1 is a covalent PROTAC degrader targeting ZBP1, with a DC50 of 25.69 nM. ZBP1 Covalent PROTAC-1 integrates a ZBP1-binding DNA aptamer, a linker containing covalent NASA, and an E3 ligase-recruiting moiety to guide ubiquitin-proteasome system-mediated degradation of ZBP1. ZBP1 Covalent PROTAC-1 exhibits inhibitory activity against necroptosis signaling pathways and inflammatory responses. ZBP1 Covalent PROTAC-1 can be used for research on viral pneumonia .
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Cat. No.: HY-N9454
CAS No.: 91893-83-3
Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae α-glucosidase and human DNA polymerase β (IC50=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia .
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Cat. No.: HY-100442S1
Purity:  98.19%
Synonyms: ABR-215757-d5-1; ABR 25757-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
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Cat. No.: HY-126085R
CAS No.: 17795-26-5
Synonyms: (±)-L-Alliin (Standard)
(±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .
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Cat. No.: HY-100442R
CAS No.: 248282-01-1
Synonyms: ABR-215757 (Standard); ABR 25757 (Standard)
Paquinimod (Standard) is the analytical standard of Paquinimod. This product is intended for research and analytical applications. Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
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Cat. No.: HY-100442S
Synonyms: ABR-215757-d5; ABR 25757-d5
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
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Cat. No.: HY-P990177

Target:  

Notch Influenza Virus

Research Areas:  

Infection Inflammation/Immunology

Anti-Mouse Notch4 Antibody (HMN4-14) is an anti-mouse Notch4 IgG monoclonal antibody. Anti-Mouse Notch4 Antibody (HMN4-14) reduces inflammation by restoring the expression of bispecific proteins. Anti-Mouse Notch4 Antibody (HMN4-14) can inhibit Th2/Th17 cell differentiation and improve Treg cell function. Anti-Mouse Notch4 Antibody (HMN4-14) can be used for research on inflammation conditions such as viral pneumonia and airway inflammation .
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Cat. No.: HY-165603
CAS No.: 3006860-57-4
Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases .
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Cat. No.: HY-185102
Target:  

PROTACs RIP kinase

Research Areas:  

Infection Inflammation/Immunology

ZBP1 PROTAC-1 is a PROTAC degrader targeting ZBP1, with a DC50 of 81.52 nM. ZBP1 PROTAC-1 uses a DNA aptamer to specifically bind ZBP1, recruits the VHL E3 ubiquitin ligase, and induces ZBP1 degradation via the ubiquitin-proteasome pathway. ZBP1 PROTAC-1 can partially restore the viability of H1N1-infected cells. ZBP1 PROTAC-1 can be used in studies related to viral pneumonia and influenza A H1N1 virus infection .
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