786593-06-4
Chemical Structure
Dehydroandrographolide succinate
- CAS No.: 786593-06-4
- Formula:C28H36O10
- Molecular Weight:532.58
IUPAC Name: 4-(((1R,2R,4aR,5R,8aS)-2-((3-carboxypropanoyl)oxy)-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)vinyl)decahydronaphthalen-1-yl)methoxy)-4-oxobutanoic acid
InChIKey: YTHKMAIVPFVDNU-GPTWTFMPSA-N
SMILES: O=C(OC[C@]1(C)[C@H](OC(CCC(O)=O)=O)CC[C@@]2(C)[C@H](/C=C/C3=CCOC3=O)C(CC[C@]12[H])=C)CCC(O)=O
Biological Activity: Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dehydroandrographolide succinate | 99.34% | Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways. | ||||||||||||||||||||
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- [1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenousadministration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6. [Content Brief]
- [2]. Bowen Yin, et al., The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies. (2022). The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies. Pharmaceutical Biology, 60(1), 175–184.
- [3]. Jin, H.,et al., (2025). Dehydroandrographolide succinate attenuates dexamethasone-induced skeletal muscle atrophy by regulating Akt/GSK3β and MuRF-1 pathways. European journal of pharmacology, 990, 177265. [Content Brief]
Keywords
