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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
vitamin D3 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "vitamin D3 receptor" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-32343
CAS No.: 55721-11-4
Synonyms: (24R)-24,25-Dihydroxyvitamin D3
Target:
2
2 Cited Publications
Target:
Research Areas:
TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .
1
1 Cited Publications
Target:
Research Areas:
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .
1
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities . Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
Target:
Research Areas:
TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research .
1
1 Cited Publications
Cat. No.: HY-P81203
Synonyms: vitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 1 antibody 1,25-@dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D hormone receptor; vitamin D receptor; vitamin D3 receptor,
1
1 Cited Publications
1
1 Cited Publications
Cat. No.: HY-P73543
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VDR; vitamin D receptor; NR1I1; Nuclear receptor Subfamily 1 Group I Member 1; 1,25-Dihydroxyvitamin D3 receptor; vitamin D3 receptor; PPP1R163; vitamin D (1,25-Dihydroxyvitamin D3) receptor; Protein Phosphatase 1, Regulatory Subunit 163; 1,25-Dihydroxyvi
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-76814
CAS No.: 78782-99-7
Cat. No.: HY-N10508
CAS No.: 71204-89-2
Target:
Synonyms: 1α,25-Dihydroxy-3-epi-vitamin-D3
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .
Cat. No.: HY-77278
CAS No.: 39932-44-0
Target:
Research Areas:
25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1 .
Cat. No.: HY-154825
CAS No.: 651734-12-2
Synonyms: 20(OH)D3; 20S-Hydroxyvitamin D3
Research Areas:
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .
Cat. No.: HY-10002S1
CAS No.: 128723-16-0
Synonyms: 1,25-Dihydroxyvitamin D3-d3
Cat. No.: HY-75041
CAS No.: 73837-24-8
Target:
Research Areas:
Calcitriol Impurities A is an impurity of Calcitriol (HY-10002). Calcitriol is the active metabolite of vitamin D3 and can activate the vitamin D receptor.
Cat. No.: HY-75035
CAS No.: 113082-99-8
Target:
Research Areas:
Calcipotriol Impurity C is an impurity of Calcipotriol (HY-10001). Calcipotriol is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor.
Cat. No.: HY-77274
CAS No.: 103656-40-2
Target:
Research Areas:
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
Impurity C of Calcitriol is the impurity of Calcitriol (HY-10002). Calcitriol is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
Cat. No.: HY-P73542
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VDR; vitamin D receptor; NR1I1; Nuclear receptor Subfamily 1 Group I Member 1; 1,25-Dihydroxyvitamin D3 receptor; vitamin D3 receptor; PPP1R163; vitamin D (1,25-Dihydroxyvitamin D3) receptor; Protein Phosphatase 1, Regulatory Subunit 163; 1,25-Dihydroxyvi
Species:
Mouse
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
