2. Anti-infection
  3. Bacterial
  4. T3SS-IN-6

T3SS-IN-6 is a thiazolidin-2-cyanamide derivative and type III secretion system (T3SS) inhibitor targeting Xanthomonas oryzae pv. oryzae (Xoo). T3SS-IN-6 exhibits no effect on Xoo growth. T3SS-IN-6 shows no measurable acute toxicity to silkworms and earthworms.

For research use only. We do not sell to patients.

T3SS-IN-6

T3SS-IN-6 Chemical Structure

CAS No. : 2231764-36-4

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T3SS-IN-6 Related Antibodies

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Description

T3SS-IN-6 is a thiazolidin-2-cyanamide derivative and type III secretion system (T3SS) inhibitor targeting Xanthomonas oryzae pv. oryzae (Xoo). T3SS-IN-6 exhibits no effect on Xoo growth. T3SS-IN-6 shows no measurable acute toxicity to silkworms and earthworms[1].

In Vitro

T3SS-IN-6 (II-2) (100-200 μM; 2 h) significantly inhibits the luciferase activity mediated by the type III secretion system (T3SS) of Xoo[1].
T3SS-IN-6 (100-200 μM; 24 h) significantly inhibits the hypersensitive response induced by Xoo in leaves of Nicotiana benthamiana[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T3SS-IN-6 Related Antibodies
In Vivo

T3SS-IN-6 (II-2) (25-200 μg/mL; mulberry leaf soaking method; single administration; 96 h) shows no acute toxicity to the silkworm (Bombyx mori) larval model, with LC50 values all greater than 200 μg/mL at 24-96 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bombyx mori larvae[1]
Dosage: 25, 50, 100, 200 μg/mL
Administration: Orali via diet
Result: No mortality or visible toxic symptoms were observed in silkworm larvae at any tested concentration over 96 h.
The LC50 values at 24, 48, 72 and 96 h were all greater than 200 μg/mL.
Molecular Weight

342.33

Formula

C15H10N4O4S
CAS No.
SMILES

O=C(N1/C(SCC1)=N/C#N)C2=CC=C(O2)C3=CC=CC=C3[N+]([O-])=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T3SS-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T3SS-IN-62231764-36-4Bacterialtype III secretion systemearthwormsXanthomonas oryzae pv. oryzaesilkwormsInhibitorinhibitorinhibit

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