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Cat. No.: HY-182364

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T3SS-IN-6

T3SS-IN-6 is a thiazolidin-2-cyanamide derivative and type III secretion system (T3SS) inhibitor targeting Xanthomonas oryzae pv. oryzae (Xoo). T3SS-IN-6 exhibits no effect on Xoo growth. T3SS-IN-6 shows no measurable acute toxicity to silkworms and earthworms.

For research use only. We do not sell to patients.

CAS No.: 2231764-36-4
Formula: C₁₅H₁₀N₄O₄S
Molecular Weight:342.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

T3SS-IN-6 Chemical Structure

CAS No.: 2231764-36-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

T3SS-IN-6 (II-2) (100-200 μM; 2 h) significantly inhibits the luciferase activity mediated by the type III secretion system (T3SS) of Xoo^[1].
T3SS-IN-6 (100-200 μM; 24 h) significantly inhibits the hypersensitive response induced by Xoo in leaves of Nicotiana benthamiana^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

T3SS-IN-6 (II-2) (25-200 μg/mL; mulberry leaf soaking method; single administration; 96 h) shows no acute toxicity to the silkworm (Bombyx mori) larval model, with LC₅₀ values all greater than 200 μg/mL at 24-96 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Bombyx mori larvae^[1]
Dosage:

25, 50, 100, 200 μg/mL
Administration:

Orali via diet
Result:

No mortality or visible toxic symptoms were observed in silkworm larvae at any tested concentration over 96 h.
The LC₅₀ values at 24, 48, 72 and 96 h were all greater than 200 μg/mL.

Chemical Information

CAS No. 2231764-36-4
Molecular Weight 342.33
Formula C₁₅H₁₀N₄O₄S
SMILES

O=C(N1/C(SCC1)=N/C#N)C2=CC=C(O2)C3=CC=CC=C3[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Siddique F, et al. A Novel Thiazolidin-2-Cyanamide Derivative Suppresses Bacterial Blight by Targeting the Type III Secretion System and Reassembling a Protective Rice Leaf Microbiome. J Agric Food Chem. 2026;74(12):10157-10167. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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