TSPBA
Based on 1 Customer Validation
TSPBA is a bis-terminal phenylboronic acid-spacer diammonium salt crosslinker. TSPBA forms dynamic phenylboronate ester bonds with PVA, enabling the preparation of injectable self-healing hydrogels and endowing them with injectability, self-healing property, ROS-responsive degradation, tissue adhesion, and weak glucose-binding ability. TSPBA is applicable to research related to diabetic wounds.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 2222566-33-6
- Formula: C21H34B2Br2N2O4
- Molecular Weight:559.94
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TSPBA (3 w/v%; 2 days) containing PATA hydrogels disrupt MSSA, MRSA, and E. coli biofilms in vitro, as evidenced by SEM visualization of dispersed biofilms, with bacterial lysis restricted to SF-loaded hydrogel formulations[1].
TSPBA (3 w/v%; 2 h) containing PATA hydrogels scavenge over 60% of intracellular ROS in H2O2-stimulated L929 fibroblast cells in vitro[1].
TSPBA (3 w/v%; 24 h) containing PATA hydrogels do not reduce glucose concentrations in L929 fibroblast cell culture supernatants in vitro, while MH-loaded PATA hydrogel formulations do lower supernatant glucose levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222566-33-6
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Appearance Solid
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Molecular Weight 559.94
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Formula C21H34B2Br2N2O4
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Color White to off-white
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SMILES
OB(C1=CC=C(C[N+](C)(CCC[N+](C)(CC2=CC=C(B(O)O)C=C2)C)C)C=C1)O.[Br-].[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : ≥ 100 mg/mL (178.59 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Chen R, et al. A multifunctional injectable, self-healing, and adhesive hydrogel-based wound dressing stimulated diabetic wound healing with combined reactive oxygen species scavenging, hyperglycemia reducing, and bacteria-killing abilities. Journal of nanobiotechnology. 2024 Jul 27;22(1):444. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7859 mL | 8.9295 mL | 17.8591 mL | 44.6476 mL |
| 5 mM | 0.3572 mL | 1.7859 mL | 3.5718 mL | 8.9295 mL | |
| 10 mM | 0.1786 mL | 0.8930 mL | 1.7859 mL | 4.4648 mL | |
| 15 mM | 0.1191 mL | 0.5953 mL | 1.1906 mL | 2.9765 mL | |
| 20 mM | 0.0893 mL | 0.4465 mL | 0.8930 mL | 2.2324 mL | |
| 25 mM | 0.0714 mL | 0.3572 mL | 0.7144 mL | 1.7859 mL | |
| 30 mM | 0.0595 mL | 0.2977 mL | 0.5953 mL | 1.4883 mL | |
| 40 mM | 0.0446 mL | 0.2232 mL | 0.4465 mL | 1.1162 mL | |
| 50 mM | 0.0357 mL | 0.1786 mL | 0.3572 mL | 0.8930 mL | |
| 60 mM | 0.0298 mL | 0.1488 mL | 0.2977 mL | 0.7441 mL | |
| 80 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5581 mL | |
| 100 mM | 0.0179 mL | 0.0893 mL | 0.1786 mL | 0.4465 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TSPBA Related Classifications
HY-185646 Related Classifications
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