2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin inhibitor 40

Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with IC50 of 1.2 μM. Tubulin inhibitor 40 shows selective cytotoxicity towards cancer cells. Tubulin inhibitor 40 processes antitumor activity .

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Tubulin inhibitor 40

Tubulin inhibitor 40 Chemical Structure

CAS No. : 3026839-57-3

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Tubulin inhibitor 40 Related Antibodies

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Description

Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with IC50 of 1.2 μM. Tubulin inhibitor 40 shows selective cytotoxicity towards cancer cells. Tubulin inhibitor 40 processes antitumor activity [1].

IC50 & Target

0.005 μM (Tubulin, A549), 0.008 μM (Tubulin, VA13), 0.009 μM (Tubulin, MCF7’), 0.008 μM (Tubulin, HEK293T)[1]
In Vitro

Tubulin inhibitor 40 reveals cytotoxicity towards cell lines A549, VA13, MCF7’ and HEK293T, with IC50 values of 0.005 μM, 0.008 μM, 0.009 μM and 0.008 μM, respectively [1].
Tubulin inhibitor 40 inhibits tubulin polymerization with IC50 of 1.2 μM [1].
Tubulin inhibitor 40 (1-25 μM, 24 h) causes changes in cell morphology and tubulin assembly in A549[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 40 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, VA13, MCF7’, HEK293T
Concentration: a range of concentrations from a few nM to 100 μM
Incubation Time: 72 h
Result: Showed cytotoxicity towards cell lines A549, VA13, MCF7’ and HEK293T.
In Vivo

Tubulin inhibitor 40 (i.v., 20 mg/kg, 5 days) processes antitumor activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: antitumor efficacy in murine L1210 and P388 leukemia in BALB/c nude mice[1]
Dosage: 20 mg/kg, i.v., 5 days
Administration: intravenous injection
Result: Showed T/C values of 233% and 324% for P388 and L1210 leukemia.
Animal Model: Antitumor Efficacy in Human Cancer Xenografts.SW620 in BALB/c nude mice[1]
Dosage: 20 mg/kg, i.v., 5 days
Administration: i.v. .intravenous injection
Result: Reduced tumor growth by 74%.
Molecular Weight

356.37

Formula

C19H20N2O5
CAS No.
SMILES

COC1=C(C(OC)=CC(C2=CON=C2C3=CC=C(C(N)=C3)OC)=C1)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 40 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 403026839-57-3Tubulin inhibitor40Tubulin inhibitor-40Microtubule/TubulinantitumortubulinA549VA13MCF7’HEK293TBALB/c nude miceInhibitorinhibitorinhibit

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