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UMB68 sodium 

Cat. No.: HY-135034
Handling Instructions

UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.

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UMB68 sodium Chemical Structure

UMB68 sodium Chemical Structure

CAS No. : 581099-89-0

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Description

UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].

IC50 & Target

GHB receptor[1]

In Vitro

UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].
UMB68 showes no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].

In Vivo

UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1].

Animal Model: Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1]
Dosage: 320, 660, 1000, 1778 mg/kg
Administration: I.p. injection
Result: Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
Molecular Weight

154.14

Formula

C₆H₁₁NaO₃

CAS No.

581099-89-0

SMILES

CC(C)(O)CCC(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

UMB68UMB 68UMB-68OthersGHBNCS-382cerebrocorticalmembranesGABInhibitorinhibitorinhibit

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UMB68 sodium
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