Carnostatine
Based on 2 publication(s) in Google Scholar
Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN).
For research use only. We do not sell to patients.
- Formula: C10H16N4O4
- Molecular Weight:256.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Carnostatine
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Biological Activity
Description
IC50 & Target
Ki: 11 nM (human CN1)[1]
In Vitro
Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 μM, i.e., close to the Km of 190 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
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Dosage:3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
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Administration:Single bolus administration
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Result:Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Chemical Information
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Molecular Weight 256.26
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Formula C10H16N4O4
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Synonyms
SAN9812
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [Abstract]2026 May 2;23(1):206. PMID: 42069589 -
Cell Death Discov
Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2-FASN axis. [Abstract]2026 Apr 9;12(1):242. PMID: 41956989
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carnostatine Related Classifications
HY-112431 Related Classifications
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