DNA polymerase lambda
Definition:
References:
-
[1]. S Aoufouchi, et al. Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 2000 Sep 15;28(18):3684-93. [Content Brief]
[2]. Andrew Craxton, et al. PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. Nat Commun. 2018 Sep 24;9(1):3877. [Content Brief]
[3]. K Nagasawa, et al. Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzyme. J Biol Chem. 2000 Oct 6;275(40):31233-8. [Content Brief]
[4]. Gloria Terrados, et al. Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS One. 2009 Oct 6;4(10):e7290. [Content Brief]
[5]. Igor Shevelev, et al. Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Res. 2003 Dec 1;31(23):6916-25. [Content Brief]
[6]. Giuseppina Blanca, et al. Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Biochemistry. 2003 Jun 24;42(24):7467-76. [Content Brief]
[7]. M García-Díaz, et al. Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. J Biol Chem. 2001 Sep 14;276(37):34659-63. [Content Brief]
[8]. Jean-Pascal Capp, et al. The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. Carcinogenesis. 2010 Oct;31(10):1742-7. [Content Brief]
[9]. Giovanni Maga, et al. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. J Biol Chem. 2005 Jan 21;280(3):1971-81. [Content Brief]
Molarity Calculator
Dilution Calculator
