USF2 - upstream transcription factor 2, c-fos interacting Gene

Also Known as FIP; bHLHb12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7392

About USF2

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,268,962-35,279,821 (from NCBI)

This gene has 16 transcripts (splice variants), 247 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

USF2 Products (3)

mRNA Protein Name
NM_001321150.2 NP_001308079.1 upstream stimulatory factor 2 isoform 3
NM_003367.4 NP_003358.1 upstream stimulatory factor 2 isoform 1
NM_207291.3 NP_997174.1 upstream stimulatory factor 2 isoform 2

USF2 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (236 - 290)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

upstream stimulatory factor 2

  • c-fos interacting protein

USF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USF2 Q15853 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
Intra
USF2 Q15853 TEAD2 Homo sapiens Q15562
Validated Y2H
25416956
Intra
USF2 Q15853 TEAD2 Homo sapiens Q15562
Y2H Prey Pooling
25416956
Intra
USF2 Q15853 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
USF2 Q15853 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

USF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810938 USF2 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Spinocerebellar Ataxia 23

  • Spinocerebellar Ataxia Type 23

  • SCA23

  • Ataxia, Spinocerebellar, Type 23
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Hyperlipidemia, Familial Combined, 3

  • Familial Combined Hyperlipidemia

  • Combined Hyperlipidemia, Familial

  • Mixed Hyperlipidaemia

  • FCHL3

  • Hyperlipidemia, Familial Combined

  • Familial Multiple Lipoprotein-Type Hyperlipidemia

  • Hyperbetalipoproteinemia With Prebetalipoproteinemia

  • Type Iib Hyperlipoproteinemia

  • Hyperlipidemia Familial Combined

  • Hyperlipoproteinemia Type Iib

  • Mixed Hyperlipemia

  • Hyperlipidaemia, Group C

  • Familial Hypercholesterolaemia With Hyperlipaemia

  • Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

  • Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

  • Hypercholesterolaemia With Endogenous Hyperglyceridaemia

  • Prebetalipoproteinemia Hyperbetalipoproteinaemia

  • Remnant Hyperlipoproteinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15514 USF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21454 Usf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27972 Usf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USF2 RGD RGD:620975
Canis familiaris USF2 VGNC VGNC:53999
Mus musculus USF2 MGD MGI:99961
Others USF2 NCBI