VPC 23153

Cat. No.: HY-W040167: Data Sheet Handling Instructions
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VPC 23153 is a S1P₄ receptor agonist and vasoconstrictor. VPC 23153 activates the S1P₄ receptor, thereby triggering vasoconstriction. VPC 23153 induces pulmonary artery contraction. VPC 23153 can be used in studies related to pulmonary arterial hypertension.

For research use only. We do not sell to patients.

VPC 23153 Chemical Structure

CAS No. : 787582-98-3

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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Description

IC₅₀ & Target^[1]

S1PR4

In Vitro

VPC 23153 (0.01-3 μM) induces dose-dependent vasoconstriction in isolated perfused normotensive rat lungs^[1].
VPC 23153 (0.1-10 μM) induces concentration-dependent contraction of isolated pulmonary arteries (but not renal or mesenteric arteries) from chronically hypoxic rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

369.40

Formula

C₁₇H₂₈N₃O₄P

CAS No.

787582-98-3

SMILES

[C@@H](COP(=O)(O)O)(N)C=1NC=2C(N1)=CC=C(CCCCCCCC)C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ota H, et al. S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. Pulm Circ. 2011;1(3):399-404. [Content Brief]

VPC 23153 Related Classifications

Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC 23153787582-98-3VPC23153VPC-23153LPL ReceptorLysophospholipid Receptorchronically hypoxic ratschronically hypoxic hypertensive rat lungspulmonary arteriespulmonary vasculaturemesenteric arteriespulmonary hypertensionS1P4 receptornormotensive rat lungsrenal arteriesInhibitorinhibitorinhibit

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