2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. YW2036

YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of colorectal cancer (CRC).

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YW2036

YW2036 화학구조

CAS No. : 2131223-92-0

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

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YW2036 Related Antibodies

Top Publications Citing Use of Products

View All Wnt Isoform Specific Products:

View All Isoforms
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of colorectal cancer (CRC)[1].

Cellular Effect
Cell Line Type Value Description References
SW480 GI50
23.9 μM
Compound: 1a
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
[PMID: 31769984]
분자량

328.37

화학식

C20H16N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)N(C2=CC=CC=C2)N=C1)NC3=CC=C4C=CC=CC4=N3
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

DMSO : 125 mg/mL (380.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0453 mL 15.2267 mL 30.4535 mL
5 mM 0.6091 mL 3.0453 mL 6.0907 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0453 mL 15.2267 mL 30.4535 mL 76.1336 mL
5 mM 0.6091 mL 3.0453 mL 6.0907 mL 15.2267 mL
10 mM 0.3045 mL 1.5227 mL 3.0453 mL 7.6134 mL
15 mM 0.2030 mL 1.0151 mL 2.0302 mL 5.0756 mL
20 mM 0.1523 mL 0.7613 mL 1.5227 mL 3.8067 mL
25 mM 0.1218 mL 0.6091 mL 1.2181 mL 3.0453 mL
30 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5378 mL
40 mM 0.0761 mL 0.3807 mL 0.7613 mL 1.9033 mL
50 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL
60 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
80 mM 0.0381 mL 0.1903 mL 0.3807 mL 0.9517 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.7613 mL
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YW2036 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YW20362131223-92-0YW 2036YW-2036Wntβ-cateninBeta catenincancerInhibitorinhibitorinhibit

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상품명:
YW2036
Cat. No.:
HY-153214
수량:
MCE Japan Authorized Agent:

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