2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. 2-O-trans-p-Coumaroylalphitolic acid

2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity.

For research use only. We do not sell to patients.

2-O-trans-p-Coumaroylalphitolic acid

2-O-trans-p-Coumaroylalphitolic acid Chemical Structure

CAS No. : 67911-63-1

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2-O-trans-p-Coumaroylalphitolic acid Related Antibodies

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Description

2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
2 μM
Compound: 29
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27617953]
In Vivo

2-O-trans-P-Coumaroylalphitolic acid (50 mg/kg, intrabitoneal injection every day for 2 weeks) has anti-obesity effects on obese mice with high fat diet (DIO) and db/db mice [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DIO mice[1]
Dosage: 50 mg/kg
Administration: i.p. every day for 2 weeks
Result: Enhanced insulin sensitivity.
Repressed. the expression of Agrp, Npy and Cdkn1a in the ARC
Molecular Weight

618.84

Formula

C39H54O6
CAS No.
SMILES

[H][C@]12CC[C@@]3([C@]4([C@@H](CC[C@@]4(CC[C@]3([C@@]1(CC[C@]5(C(C)([C@H]([C@@H](C[C@]25C)OC(/C=C/C6=CC=C(C=C6)O)=O)O)C)[H])C)C)C(O)=O)C(C)=C)[H])[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-O-trans-p-Coumaroylalphitolic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-O-trans-p-Coumaroylalphitolic acid67911-63-1Glucocorticoid ReceptorZj7glucocorticoid receptormodulatorDIOdb/db miceInhibitorinhibitorinhibit

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