3,4',5-Trismethoxybenzophenone
Based on 1 Customer Validation
3,4',5-Trismethoxybenzophenone (compound 16a) is a potent tubulin assembly inhibitor with an IC50 value of 2.6 µM.
For research use only. We do not sell to patients.
- Purity : 95.61%
- CAS No.: 94709-12-3
- Formula: C16H16O4
- Molecular Weight:272.30
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Trimethyl [2,2':6',2''-terpyridine]-4,4',4''-tricarboxylateDrug Intermediate -
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GKT136901NOX1/4 Inhibitor -
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Flavokawain A (Standard)Anti-tumor Agent -
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3,5-Dihydroxybenzaldehydeα-glucosidase Inhibitor -
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δ-CEHCEndogenous Metabolite -
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GKT136901 (Standard)NOX1/4 Inhibitor
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | GI50 |
0.42 μg/mL
Compound: 16a
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Cell growth inhibition against pancreatic BXPC-3 cells, 50% reduction in the net protein increase
Cell growth inhibition against pancreatic BXPC-3 cells, 50% reduction in the net protein increase
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[PMID: 12036362] |
| DU-145 | GI50 |
1.2 μg/mL
Compound: 16a
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Cell growth inhibition of prostate DU-145 cells, expressed as 50% reduction in the net protein increase
Cell growth inhibition of prostate DU-145 cells, expressed as 50% reduction in the net protein increase
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[PMID: 12036362] |
| KM-20L2 | GI50 |
0.42 μg/mL
Compound: 16a
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Cell growth inhibition of colon KM20L2 cells, expressed as 50% reduction in the net protein increase
Cell growth inhibition of colon KM20L2 cells, expressed as 50% reduction in the net protein increase
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[PMID: 12036362] |
| NCI-H460 | GI50 |
0.53 μg/mL
Compound: 16a
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Cell growth inhibition of lung-NSC NCI-H460 cells, expressed as 50% reduction in the net protein increase
Cell growth inhibition of lung-NSC NCI-H460 cells, expressed as 50% reduction in the net protein increase
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[PMID: 12036362] |
| P388 | ED50 |
1.23 μg/mL
Compound: 16a
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Evaluated for cell growth inhibition of the mouse leukemia P388 cells in 10% horse serum/Fisher media
Evaluated for cell growth inhibition of the mouse leukemia P388 cells in 10% horse serum/Fisher media
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[PMID: 12036362] |
| SF-268 | GI50 |
0.86 μg/mL
Compound: 16a
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Cell growth inhibition of central nervous system (CNS) SF-268 cells, expressed as 50% reduction in the net protein increase
Cell growth inhibition of central nervous system (CNS) SF-268 cells, expressed as 50% reduction in the net protein increase
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[PMID: 12036362] |
Chemical Information
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CAS No. 94709-12-3
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Appearance Solid
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Molecular Weight 272.30
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Formula C16H16O4
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Color White to off-white
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SMILES
O=C(C1=CC(OC)=CC(OC)=C1)C2=CC=C(OC)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3,4',5-Trismethoxybenzophenone Related Classifications
HY-120890 Related Classifications
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