3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 (Synonyms: 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether)

Name: 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
Brand: MedChemExpress
SKU: HY-15254
Rating: 4.5 (1 reviews)

Cat. No.: HY-15254 Purity: 99.28%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.

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3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 화학구조

CAS No. : 163018-26-6

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

•Virol Sin. 2024 Aug 19:S1995-820X(24)00134-2. [Abstract]

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.

IC₅₀ & Target

Vitamin D/Vitamin D receptor^[1]

In Vitro

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a 25-hydroxyvitamin D3 derivative^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

457.73

화학식

C₃₀H₅₁NO₂

CAS No.

163018-26-6

Appearance

Solid

Color

White to off-white

SMILES

C=C1CC[C@H](OCCCN)C/C1=C/C=C2[C@@](CC[C@]3([H])[C@@H](CCCC(C)(C)O)C)([H])[C@]3(C)CCC/2

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (218.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1847 mL	10.9235 mL	21.8469 mL
5 mM	0.4369 mL	2.1847 mL	4.3694 mL
10 mM	0.2185 mL	1.0923 mL	2.1847 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.28%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Roy A, et al. Aminopropylation of vitamin D hormone (1α,25-dihydroxyvitamin D3), its biological precursors, and other steroidal alcohols: an anchoring moiety for affinity studies of sterols. Steroids (1995), 60(8), 530-3. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1847 mL	10.9235 mL	21.8469 mL	54.6173 mL
	5 mM	0.4369 mL	2.1847 mL	4.3694 mL	10.9235 mL
	10 mM	0.2185 mL	1.0923 mL	2.1847 mL	5.4617 mL
	15 mM	0.1456 mL	0.7282 mL	1.4565 mL	3.6412 mL
	20 mM	0.1092 mL	0.5462 mL	1.0923 mL	2.7309 mL
	25 mM	0.0874 mL	0.4369 mL	0.8739 mL	2.1847 mL
	30 mM	0.0728 mL	0.3641 mL	0.7282 mL	1.8206 mL
	40 mM	0.0546 mL	0.2731 mL	0.5462 mL	1.3654 mL
	50 mM	0.0437 mL	0.2185 mL	0.4369 mL	1.0923 mL
	60 mM	0.0364 mL	0.1821 mL	0.3641 mL	0.9103 mL
	80 mM	0.0273 mL	0.1365 mL	0.2731 mL	0.6827 mL
	100 mM	0.0218 mL	0.1092 mL	0.2185 mL	0.5462 mL

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3163018-26-625-Hydroxy Vitamin D3 3,3’-Aminopropyl EtherVD/VDRVitamin DVitamin D receptorInhibitorinhibitorinhibit

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3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 (Synonyms: 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether)

고객리뷰

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Related Antibodies

1 Publications Citing Use of MCE 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report