3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
Based on 1 publication(s) in Google Scholar
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
For research use only. We do not sell to patients.
- Purity : 99.28%
- CAS No.: 163018-26-6
- Formula: C30H51NO2
- Molecular Weight:457.73
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Storage:
4°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
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Biological Activity
Description
IC50 & Target
Vitamin D/Vitamin D receptor[1]
In Vitro
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a 25-hydroxyvitamin D3 derivative[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 163018-26-6
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Appearance Solid
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Molecular Weight 457.73
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Formula C30H51NO2
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Color White to off-white
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SMILES
C=C1CC[C@H](OCCCN)C/C1=C/C=C2[C@@](CC[C@]3([H])[C@@H](CCCC(C)(C)O)C)([H])[C@]3(C)CCC/2
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Synonyms
25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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Virol Sin
Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. [Abstract]2024 Oct;39(5):802-811. PMID: 39168248
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (218.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1847 mL | 10.9235 mL | 21.8469 mL | 54.6173 mL |
| 5 mM | 0.4369 mL | 2.1847 mL | 4.3694 mL | 10.9235 mL | |
| 10 mM | 0.2185 mL | 1.0923 mL | 2.1847 mL | 5.4617 mL | |
| 15 mM | 0.1456 mL | 0.7282 mL | 1.4565 mL | 3.6412 mL | |
| 20 mM | 0.1092 mL | 0.5462 mL | 1.0923 mL | 2.7309 mL | |
| 25 mM | 0.0874 mL | 0.4369 mL | 0.8739 mL | 2.1847 mL | |
| 30 mM | 0.0728 mL | 0.3641 mL | 0.7282 mL | 1.8206 mL | |
| 40 mM | 0.0546 mL | 0.2731 mL | 0.5462 mL | 1.3654 mL | |
| 50 mM | 0.0437 mL | 0.2185 mL | 0.4369 mL | 1.0923 mL | |
| 60 mM | 0.0364 mL | 0.1821 mL | 0.3641 mL | 0.9103 mL | |
| 80 mM | 0.0273 mL | 0.1365 mL | 0.2731 mL | 0.6827 mL | |
| 100 mM | 0.0218 mL | 0.1092 mL | 0.2185 mL | 0.5462 mL |
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Related Classifications
HY-15254 Related Classifications
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