4-Azidobutyric acid
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4-Azidobutyric acid is a click chemistry reagent featuring azide and carboxylic acid moieties. The carboxylic acid group can conjugate with alcohols or amides, while the azide group serves as a click chemistry handle to react with terminal alkynes or strained cyclooctynes. 4-Azidobutyric acid also acts as a PROTAC linker for the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 54447-68-6
- Formula: C4H7N3O2
- Molecular Weight:129.12
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
4-Azidobutyric acid serves as a precursor in the synthesis of succinimidyl 4-azidobutyrate for thiol-PEG-azide preparation[1].
4-Azidobutyric acid acts as a precursor for the synthesis of N-acylbenzotriazole bioconjugation reagents for protein functionalization via azide-alkyne cycloaddition reactions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 54447-68-6
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Appearance Liquid
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Molecular Weight 129.12
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Formula C4H7N3O2
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Color Colorless to light yellow
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SMILES
[N-]=[N+]=NCCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (1548.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Cui L, et al. Integrin αvβ3-Targeted [Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjugate chemistry. 2018 Dec 19;29(12):4062-4071. [Content Brief]
[2]. Suhorepec N, et al. Synthesis of Bioconjugation Reagents for Use in Covalent Cross-Linking of Proteins by Azide-Alkyne Cycloaddition. Molecules (Basel, Switzerland). 2025 Dec 02;30(23):4623. [Content Brief]
[3]. Ning Yang, et al. Discovery of highly potent and selective KRASG12Cdegraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation. Eur J Med Chem. 2023 Dec 5:261:115857. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.7447 mL | 38.7237 mL | 77.4473 mL | 193.6183 mL |
| 5 mM | 1.5489 mL | 7.7447 mL | 15.4895 mL | 38.7237 mL | |
| 10 mM | 0.7745 mL | 3.8724 mL | 7.7447 mL | 19.3618 mL | |
| 15 mM | 0.5163 mL | 2.5816 mL | 5.1632 mL | 12.9079 mL | |
| 20 mM | 0.3872 mL | 1.9362 mL | 3.8724 mL | 9.6809 mL | |
| 25 mM | 0.3098 mL | 1.5489 mL | 3.0979 mL | 7.7447 mL | |
| 30 mM | 0.2582 mL | 1.2908 mL | 2.5816 mL | 6.4539 mL | |
| 40 mM | 0.1936 mL | 0.9681 mL | 1.9362 mL | 4.8405 mL | |
| 50 mM | 0.1549 mL | 0.7745 mL | 1.5489 mL | 3.8724 mL | |
| 60 mM | 0.1291 mL | 0.6454 mL | 1.2908 mL | 3.2270 mL | |
| 80 mM | 0.0968 mL | 0.4840 mL | 0.9681 mL | 2.4202 mL | |
| 100 mM | 0.0774 mL | 0.3872 mL | 0.7745 mL | 1.9362 mL |
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