54447-68-6
54447-68-6
Chemical Structure
4-Azidobutyric acid
- CAS No.: 54447-68-6
- Formula:C4H7N3O2
- Molecular Weight:129.12
IUPAC Name: 4-azidobutanoic acid
InChIKey: WAGMYTXJRVPMGW-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCCC(O)=O
Biological Activity: 4-Azidobutyric acid is a click chemistry reagent featuring azide and carboxylic acid moieties. The carboxylic acid group can conjugate with alcohols or amides, while the azide group serves as a click chemistry handle to react with terminal alkynes or strained cyclooctynes. 4-Azidobutyric acid also acts as a PROTAC linker for the synthesis of PROTACs[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
4-Azidobutyric acid | 99.48% | 4-Azidobutyric acid is a click chemistry reagent featuring azide and carboxylic acid moieties. The carboxylic acid group can conjugate with alcohols or amides, while the azide group serves as a click chemistry handle to react with terminal alkynes or strained cyclooctynes. 4-Azidobutyric acid also acts as a PROTAC linker for the synthesis of PROTACs. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Cui L, et al. Integrin αvβ3-Targeted [Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjugate chemistry. 2018 Dec 19;29(12):4062-4071. [Content Brief]
- [2]. Suhorepec N, et al. Synthesis of Bioconjugation Reagents for Use in Covalent Cross-Linking of Proteins by Azide-Alkyne Cycloaddition. Molecules (Basel, Switzerland). 2025 Dec 02;30(23):4623. [Content Brief]
- [3]. Ning Yang, et al. Discovery of highly potent and selective KRASG12Cdegraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation. Eur J Med Chem. 2023 Dec 5:261:115857. [Content Brief]
