Chitinase-IN-2 hydrochloride

Name: Chitinase-IN-2 hydrochloride
Brand: MedChemExpress
SKU: HY-18599A
Rating: 4.5 (2 reviews)

Cat. No.: HY-18599A Purity: 99.16%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chitinase-IN-2 hydrochloride is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively.

For research use only. We do not sell to patients.

Chitinase-IN-2 hydrochloride Chemical Structure

CAS No. : 2070014-83-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 374	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 374	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Chitinase-IN-2 hydrochloride:

Chitinase-IN-2 In-stock

1 Publications Citing Use of MCE Chitinase-IN-2 hydrochloride

•Neuroscience. 2017 May 10;355:61-70. [Abstract]

: Chitinase-IN-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Neuroscience. 2017 May 10;355:61-70. [Abstract]; Measurement of Aβ oligomers by immunohistochemical staining (×200) and western blot in experimental animals. Whether in the hippocampus (A) or cortex (B), there are much more Aβ oligomers in theAD rats compared to controls (p<0.05). Compared with the AD group, expression of Aβ oligomers in the cortex and hippocampus following chitinase treatment in AD rats is reduced (p<0.05), while the chitinase inhibitor (chitinase-IN-2) increases the Aβ oligomer expression (p<0.05)

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

431.94

Formula

C₂₀H₂₂ClN₅O₂S

CAS No.

2070014-83-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CC2=C1C3=CC=C2N(C)C)N(CCNCC4=NN=C(C)S4)C3=O.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (115.76 mM; Need ultrasonic)

DMSO : ≥ 46 mg/mL (106.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3151 mL	11.5757 mL	23.1514 mL
5 mM	0.4630 mL	2.3151 mL	4.6303 mL
10 mM	0.2315 mL	1.1576 mL	2.3151 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.16%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) HNMR (194 KB) LCMS (478 KB)

Handling Instructions (2659 KB)

References

[1]. thalimide derivative and application thereof as enzyme inhibitor and pesticide . Patent CN 103641825 A

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.3151 mL	11.5757 mL	23.1514 mL	57.8784 mL
	5 mM	0.4630 mL	2.3151 mL	4.6303 mL	11.5757 mL
	10 mM	0.2315 mL	1.1576 mL	2.3151 mL	5.7878 mL
	15 mM	0.1543 mL	0.7717 mL	1.5434 mL	3.8586 mL
	20 mM	0.1158 mL	0.5788 mL	1.1576 mL	2.8939 mL
	25 mM	0.0926 mL	0.4630 mL	0.9261 mL	2.3151 mL
	30 mM	0.0772 mL	0.3859 mL	0.7717 mL	1.9293 mL
	40 mM	0.0579 mL	0.2894 mL	0.5788 mL	1.4470 mL
	50 mM	0.0463 mL	0.2315 mL	0.4630 mL	1.1576 mL
	60 mM	0.0386 mL	0.1929 mL	0.3859 mL	0.9646 mL
	80 mM	0.0289 mL	0.1447 mL	0.2894 mL	0.7235 mL
	100 mM	0.0232 mL	0.1158 mL	0.2315 mL	0.5788 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.