Chitinase-IN-2 hydrochloride
Based on 1 publication(s) in Google Scholar
Chitinase-IN-2 hydrochloride is an inhibitor of insect chitinase and N-acetylhexosaminidase.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 2070014-83-2
- Formula: C20H22ClN5O2S
- Molecular Weight:431.94
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Chitinase-IN-2 hydrochloride
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Customer Validation & Images
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Biological Activity
Chemical Information
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CAS No. 2070014-83-2
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Appearance Solid
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Molecular Weight 431.94
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Formula C20H22ClN5O2S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC2=C1C3=CC=C2N(C)C)N(CCNCC4=NN=C(C)S4)C3=O.Cl[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuroscience
Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments. [Abstract]2017 Jul 4:355:61-70. PMID: 28499970
Chitinase-IN-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Neuroscience. 2017 Jul 4:355:61-70. [Abstract]
Measurement of Aβ oligomers by immunohistochemical staining (×200) and western blot in experimental animals. Whether in the hippocampus (A) or cortex (B), there are much more Aβ oligomers in theAD rats compared to controls (p<0.05). Compared with the AD group, expression of Aβ oligomers in the cortex and hippocampus following chitinase treatment in AD rats is reduced (p<0.05), while the chitinase inhibitor (chitinase-IN-2) increases the Aβ oligomer expression (p<0.05)
Solvent & Solubility
H2O : 50 mg/mL (115.76 mM; Need ultrasonic)
DMSO : ≥ 46 mg/mL (106.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.3151 mL | 11.5757 mL | 23.1514 mL | 57.8784 mL |
| 5 mM | 0.4630 mL | 2.3151 mL | 4.6303 mL | 11.5757 mL | |
| 10 mM | 0.2315 mL | 1.1576 mL | 2.3151 mL | 5.7878 mL | |
| 15 mM | 0.1543 mL | 0.7717 mL | 1.5434 mL | 3.8586 mL | |
| 20 mM | 0.1158 mL | 0.5788 mL | 1.1576 mL | 2.8939 mL | |
| 25 mM | 0.0926 mL | 0.4630 mL | 0.9261 mL | 2.3151 mL | |
| 30 mM | 0.0772 mL | 0.3859 mL | 0.7717 mL | 1.9293 mL | |
| 40 mM | 0.0579 mL | 0.2894 mL | 0.5788 mL | 1.4470 mL | |
| 50 mM | 0.0463 mL | 0.2315 mL | 0.4630 mL | 1.1576 mL | |
| 60 mM | 0.0386 mL | 0.1929 mL | 0.3859 mL | 0.9646 mL | |
| 80 mM | 0.0289 mL | 0.1447 mL | 0.2894 mL | 0.7235 mL | |
| 100 mM | 0.0232 mL | 0.1158 mL | 0.2315 mL | 0.5788 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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