FR183998 free base
Based on 1 Customer Validation
FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
For research use only. We do not sell to patients.
- Purity : 98.06%
- CAS No.: 239440-20-1
- Formula: C17H19Cl2N5O2S
- Molecular Weight:428.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-19693
CariporideNa+/H+ Exchange Inhibitor -
HY-15991
TenapanorNHE3 Inhibitor -
HY-19273
RimeporideNa+/H+ Exchanger Inhibitor -
HY-100325
NHE3-IN-1NHE-3 Inhibitor -
HY-100302R
FR183998 free base (Standard)Na+/H+-Exchange Inhibitor -
HY-106150B
Eniporide hydrochlorideNa+/H+ Exchange Inhibitor -
HY-105064D
Zoniporide hydrochloride hydrateNHE1 Inhibitor -
HY-139313
NHE3-IN-2NHE3 Inhibitor -
HY-19273R
Rimeporide (Standard)Na+/H+ Exchanger Inhibitor -
HY-15991A
Tenapanor hydrochlorideNHE3 Inhibitor -
HY-105064
ZoniporideNHE1 Inhibitor -
HY-19693R
Cariporide (Standard)Na+/H+ Exchange Inhibitor
Biological Activity
Description
IC50 & Target
IC50: 0.3 nM (Na+/H+-exchange, Rat lymphocytes), 3.1 nM (Na+/H+-exchange, Human platelet), 6.5 nM (Na+/H+-exchange, Rat platelet)[1]
In Vitro
FR183998 free base is a Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 6.5 nM and 3.1 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 239440-20-1
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Appearance Solid
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Molecular Weight 428.34
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Formula C17H19Cl2N5O2S
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Color White to off-white
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SMILES
O=C(C1=CC(C2=C(Cl)SC(Cl)=C2)=CC(C(NCCN(C)C)=O)=C1)NC(N)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (583.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ohara F, et al. Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion. J Cardiovasc Pharmacol. 1999 Dec;34(6):848-56. [Content Brief]
[2]. Ishizaki M, et al. Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3346 mL | 11.6730 mL | 23.3459 mL | 58.3649 mL |
| 5 mM | 0.4669 mL | 2.3346 mL | 4.6692 mL | 11.6730 mL | |
| 10 mM | 0.2335 mL | 1.1673 mL | 2.3346 mL | 5.8365 mL | |
| 15 mM | 0.1556 mL | 0.7782 mL | 1.5564 mL | 3.8910 mL | |
| 20 mM | 0.1167 mL | 0.5836 mL | 1.1673 mL | 2.9182 mL | |
| 25 mM | 0.0934 mL | 0.4669 mL | 0.9338 mL | 2.3346 mL | |
| 30 mM | 0.0778 mL | 0.3891 mL | 0.7782 mL | 1.9455 mL | |
| 40 mM | 0.0584 mL | 0.2918 mL | 0.5836 mL | 1.4591 mL | |
| 50 mM | 0.0467 mL | 0.2335 mL | 0.4669 mL | 1.1673 mL | |
| 60 mM | 0.0389 mL | 0.1945 mL | 0.3891 mL | 0.9727 mL | |
| 80 mM | 0.0292 mL | 0.1459 mL | 0.2918 mL | 0.7296 mL | |
| 100 mM | 0.0233 mL | 0.1167 mL | 0.2335 mL | 0.5836 mL |
FR183998 free base Related Classifications
HY-100302 Related Classifications
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