Homosalate
Based on 1 publication(s) in Google Scholar
Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity.
For research use only. We do not sell to patients.
- Purity : 99.4%
- CAS No.: 118-56-9
- Formula: C16H22O3
- Molecular Weight:262.34
-
Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-B0272
RifampicinAntivirus Agent -
HY-B0167
Salicylic acidCOX-2 Inhibitor -
HY-A0067
OxybenzoneUltraviolet Light Filter -
HY-16637
Folic acidB complex -
HY-50935
TroglitazonePPARγ Agonist -
HY-B0809
TheophyllinePDE Inhibitor -
HY-14519
MethotrexateDihydrofolate Reductase Inhibitor -
HY-N0378
D-MannitolResistant Sugar/Osmotic Diuretics -
HY-B0451A
Dopamine hydrochlorideCatecholamine Neurotransmitter -
HY-14187
AmiodaroneAntiarrhythmic Compound -
HY-17406
TolcaponeCOMT Inhibitor -
HY-B0710
Betaine
Publications Citing Use of MedChemExpress (MCE) Homosalate
More
Customer Validation & Images
-
WB
Biological Activity
Description
In Vitro
Homosalate (250-2000 μM, 24 h) has cytotoxic and genotoxic effects on MCF-7 cells[1].
Homosalate (10 μM) can promote the release of tumor-derived extracellular vesicles and has a protective effect against loss of anchoring[2].
Homosalate (20-100 μM, 2 h) significantly inhibits HTR8/Svneo cell invasion through PI3K/AKT and MAPK pathways[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:MCF-7
-
Concentration:250, 500, 750, 1000, 1500, 2000 μM
-
Incubation Time:24 h
-
Result:Induced micronucleus formation at 750 and 1000 µM.
Decreased cell viability up to 57% at 2000 μM.
-
Cell Line:HTR8/SVneo
-
Concentration:0, 20, 50 100 μM
-
Incubation Time:2 h
-
Result:Reduced proliferation and increased apoptotic cell ratio.
-
Cell Line:HTR8/SVneo
-
Concentration:0, 20, 50 100 μM
-
Incubation Time:2 h
-
Result:Increased the phosphorylation of ERK1/2 (p-ERK1/2) and P38 (p-P38).
Chemical Information
-
CAS No. 118-56-9
-
Appearance Liquid (Density: 1.05 g/cm3)
-
Molecular Weight 262.34
-
Formula C16H22O3
-
Color Colorless to light yellow
-
SMILES
O=C(OC1CC(C)(C)CC(C)C1)C2=CC=CC=C2O
-
Synonyms
Homomenthyl salicylate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Environ Pollut
Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. [Abstract]2018 Dec;243(Pt B):1263-1273. PMID: 30267922
Homosalate purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2018 Dec;243(Pt B):1263-1273. [Abstract]
The expression of GRP78, IRE1α, p-eIF2α, t-eIF2α, and TUBA are analyzed in response to homosalate in a dose-dependent manner (0, 50, 100, and 200 µM) for 12 h.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (381.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.53 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.53 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocols
-
Cotton Pellet Granuloma
Cotton pellet granuloma is a classical in vivo chronic inflammation model used to evaluate the anti-inflammatory potential of test substances by measuring their ability to inhibit granuloma tissue formation around an implanted foreign body (cotton pellet) in rodents. The method is based on the biological response to a sterile implanted material, which induces proliferative phase inflammation characterized by fibroblast proliferation and collagen-rich granuloma formation, and the final readout reflects the extent of chronic inflammatory tissue growth surrounding the pellet. In multiple preclinical pharmacological evaluations, inhibition of cotton pellet-induced granuloma formation has been used as an indicator of anti-inflammatory activity in both synthetic and natural product screening contexts.
-
Carrageenan-Induced Paw Edema
Carrageenan-induced paw edema is an acute inflammation model in which intraplantar injection of carrageenan induces localized inflammatory swelling characterized by vascular permeability, leukocyte infiltration, and production of inflammatory mediators such as prostaglandins and cytokines, making it widely used to evaluate anti-inflammatory agents in vivo. The resulting paw volume or thickness increase is quantified over time as a direct readout of inflammatory intensity and drug efficacy, typically reflecting cyclooxygenase-mediated prostaglandin-driven edema formation and immune cell recruitment in peripheral tissue[20].
-
Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Yazar S, et al. Assessment of the cytotoxicity and genotoxicity of homosalate in MCF-7. J Cosmet Dermatol. 2020 Jan;19(1):246-252. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
[3]. Yang C, et al. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. Environ Pollut. 2018 Dec;243(Pt B):1263-1273. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8118 mL | 19.0592 mL | 38.1185 mL | 95.2962 mL |
| 5 mM | 0.7624 mL | 3.8118 mL | 7.6237 mL | 19.0592 mL | |
| 10 mM | 0.3812 mL | 1.9059 mL | 3.8118 mL | 9.5296 mL | |
| 15 mM | 0.2541 mL | 1.2706 mL | 2.5412 mL | 6.3531 mL | |
| 20 mM | 0.1906 mL | 0.9530 mL | 1.9059 mL | 4.7648 mL | |
| 25 mM | 0.1525 mL | 0.7624 mL | 1.5247 mL | 3.8118 mL | |
| 30 mM | 0.1271 mL | 0.6353 mL | 1.2706 mL | 3.1765 mL | |
| 40 mM | 0.0953 mL | 0.4765 mL | 0.9530 mL | 2.3824 mL | |
| 50 mM | 0.0762 mL | 0.3812 mL | 0.7624 mL | 1.9059 mL | |
| 60 mM | 0.0635 mL | 0.3177 mL | 0.6353 mL | 1.5883 mL | |
| 80 mM | 0.0476 mL | 0.2382 mL | 0.4765 mL | 1.1912 mL | |
| 100 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.9530 mL |
Homosalate Related Classifications
HY-B0928 Related Classifications
Powered by Bioz