Anisomeles malabarica(L.) R.Br.
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Anisomeles malabarica(L.) R.Br. (1)
Anisomelic acid
Cat. No.: HY-N20712
CAS No.: 59632-76-7
- Formula: C20H26O4
- Molecular Weight: 330.42
Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor. Anisomelic acid directly interacts with HPV16 E6, promotes its ubiquitination and proteasomal degradation by recruiting E3 ubiquitin ligase, downregulates E6 and facilitates E7 degradation. Anisomelic acid induces endogenous mitochondrial apoptosis, activates caspase-3, causes cleavage of PARP, and triggers p53-independent endogenous apoptosis by depleting cIAP2. Anisomelic acid can be used in research related to HPV-positive cancers and cervical cancer.
