Dalbergia obtusifolia(Baker) Prain
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Dalbergia obtusifolia(Baker) Prain (1)
Obtusaquinone
Cat. No.: HY-N19738
CAS No.: 21105-15-7
- Formula: C16H14O3
- Molecular Weight: 254.28
Obtusaquinone is a blood-brain barrier-permeable Keap1 inhibitor with anticancer activity. Obtusaquinone covalently binds to cysteine residues of Keap1, promotes its ubiquitination and proteasomal degradation, and activates the Nrf2 pathway. Obtusaquinone induces endoplasmic reticulum stress and DNA damage through abnormal accumulation of ROS, and triggers apoptosis of cancer cells. Obtusaquinone prolongs survival in orthotopic xenograft models of pediatric high-grade glioma, and exhibits antitumor activity in glioblastoma and breast cancer models. Obtusaquinone can be used in studies related to glioma and breast cancer.
