Infection

Alloferon 2 is an antiviral and antitumoral peptide. Alloferon 2 can be isolated from the blood of the blow fly Calliphora vicina (Diptera).

MAC173979 is a inhibitor of PABA synthesis in E. coli. MAC173979 can be used for study of antibacterial drug development.

Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity.

F3226-1387 is a potent Entamoeba histolytica O-acetylserine sulfhydrylase EhOASS3 inhibitor with an IC₅₀ value of 38 μM. F3226-1387 can suppress the growth of the amoeba.

Efrotomycin is an orally active antibiotic. Efrotomycin can be isolated from the Streptomyces Lactamdurans. Efrotomycin has insignificant effect on Salmonella typhimurium quantity, duration, shedding rate, and antimicrobial susceptibility in infected pigs.

Sinigrin (Standard) (Allyl-glucosinolate (Standard)) is the analytical standard of Sinigrin (HY-N0404). This product is intended for research and analytical applications. Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases.

Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC₅₀ of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC₅₀ of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model.

Cabozantinib (S-malate) (Standard) is the analytical standard of Cabozantinib (S-malate). This product is intended for research and analytical applications. Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC₅₀ of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys.

Methyl N-methylanthranilate-d₃ is the deuterated-labeled Methyl N-methylanthranilate (HY-76705). Methyl N-methylanthranilate is an N-alkylated anthranilate with a sweet citrus aroma, which is commonly used in perfume manufacturing. Methyl N-methylanthranilate is the dominant component in the defensive secretion of the millipede Typhloiulus orpheus. Methyl N-methylanthranilate exhibits quorum sensing inhibition and anti-biofilm activity against P. aeruginosa; it interferes with PQS synthesis via competitive inhibition of PqsA, but lacks bactericidal activity. Methyl N-methylanthranilate is sensitive to UVA/sunlight in human skin cells, and generates O₂•^- through type I photodynamic reactions, leading to lysosomal/mitochondrial damage, double-strand DNA breaks and apoptosis, with potential phototoxicity.

BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity. BMAP-27 acetate disrupts the integrity and permeability of cell membranes, leading to the leakage of intracellular DNA, proteins and alkaline phosphatase. BMAP-27 acetate increases intracellular ROS levels and reduces plasma endotoxin and TNF-α concentrations. BMAP-27 acetate can be used in studies related to Salmonella infection, breast cancer, lung cancer and obstructive jaundice.

(+)-Chromazonarol ((+)-ent-Chromazonarol) is a marine sesquiterpene hybrid terpene and pimarane-type hybrid terpene Antifungal agent. (+)-Chromazonarol is isolated from the marine sponge Dysidea pallescens. (+)-Chromazonarol inhibits the mycelial growth of Sclerotinia sclerotiorum and Rhizoctonia solani. (+)-Chromazonarol is applicable to research related to Sclerotinia sclerotiorum infection and Rhizoctonia solani infection.

Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts.

Sulfasymazine is a sulfonamide agent and displays antibacterial properties.

RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-4 shows anti-RSV activity (EC₅₀ = 11.76 μM).

HBV-IN-46 (compound 1.6) is an active metabolite. HBV-IN-46 is a HBV S-antigen inhibitor, with an EC₅₀ of 2.6 nM.

Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

Anidulafungin-d₁₁ is the deuterium labeled Anidulafungin (HY-13553). Anidulafungin is a new semisynthetic echinocandin with antifungal potency.

Novaluron-d₃-1 is the deuterium labeled Novaluron (HY-17519). Novaluron is a chemical with?insecticide?properties, an insect growth regulator, and has adverse effects on mouse sperm.

Rubia cordifolia extract, derived from the madder plant, is valued for its anti-inflammatory, antioxidant, antibacterial, and blood-purifying properties. Active ingredients in Rubia cordifolia extract include anthraquinone compounds (such as alizarin and alizarin red), flavonoids, and tannins.