Disulfide Cleavable Linker
Disulfide cleavable linkers provide redox-responsive bonds for drug delivery because extracellular and intracellular glutathione gradients enable selective activation in reductive cytoplasmic environments[1]. Mechanistically, disulfide cleavage can release small-molecule drugs, macromolecule conjugates, or masked bioactive agents after cellular entry[2][3]. In cancer models, disulfide-containing prodrugs, nanoparticles, nanogels, vaccines, and aptamer-drug conjugates have improved controlled release, tumor-cell uptake, or antitumor response[2][4][5][6]. Compared with non-redox-responsive analogues, disulfide-linked systems showed faster drug release, stronger cellular uptake, or higher tumor-selective cytotoxicity in reported experimental models[4][7][8]. For research design, linker electronics, steric hindrance, substituent position, and biorelevant reducing agents such as glutathione should guide stability and cleavage-rate evaluation[2][9].
References:
- [1]. Deng Z, et al. Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications. Macromol Rapid Commun. 2020 Jan;41(1):e1900531. [Content Brief]
- [2]. Wang Q, et al. Disulfide based prodrugs for cancer therapy. RSC Adv. 2020 Jun 25;10(41):24397-24409. [Content Brief]
- [3]. Yang X, et al. Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery. Med Res Rev. 2020 Nov;40(6):2682-2713. [Content Brief]
- [4]. Conte C, et al. Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release. 2018 May 10;277:126-141. [Content Brief]
- [5]. Kramer K, et al. Intracellular Cleavable CpG Oligodeoxynucleotide-Antigen Conjugate Enhances Anti-tumor Immunity. Mol Ther. 2017 Jan 4;25(1):62-70. [Content Brief]
- [6]. Wu Y, et al. Improvement of Drug Release from an Aptamer Drug Conjugate Using Reductive-sensitive Linkers for Tumor-targeted Drug Delivery. AAPS J. 2025 May 20;27(4):95. [Content Brief]
- [7]. Drude N, et al. Impact of Glutathione Modulation on Stability and Pharmacokinetic Profile of Redox-Sensitive Nanogels. Small. 2018 Apr;14(14):e1704093. [Content Brief]
- [8]. Ai X, et al. Star-shape redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol-lysine-di-tocopherol succinate for tumor-triggering intracellular doxorubicin rapid release: head-to-head comparison. Macromol Biosci. 2014 Oct;14(10):1415-28. [Content Brief]
- [9]. Phillips DJ, et al. Redox-sensitive materials for drug delivery: targeting the correct intracellular environment, tuning release rates, and appropriate predictive systems. Antioxid Redox Signal. 2014 Aug 10;21(5):786-803. [Content Brief]
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Disulfide Cleavable Linker Related Products (124)
Related Products (124)
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Propargyl-PEG1-SS-PEG1-C2-Boc
0 ImagesPropargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Ald-PEG23-SPDP
0 ImagesCat. No.: HY-136309Ald-PEG23-SPDP is a cleavable 23 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Sulfo-DMAC-SPP
0 ImagesCat. No.: HY-130110CAS No.: 663599-11-9Sulfo-DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Bis-(PEG6-acid)-SS
0 ImagesCat. No.: HY-140115CAS No.: 2055014-97-4Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DMAC-SPP
0 ImagesCat. No.: HY-130111CAS No.: 663599-10-8DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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OPSS-PEG36-acid
0 ImagesCat. No.: HY-141355Purity: 98.27%OPSS-PEG36-acid is a cleavable 36 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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NO2-SPP-sulfo
0 ImagesCat. No.: HY-133547CAS No.: 663598-66-1NO2-SPP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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N-Succinimidyloxycarbonylpropyl methanethiosulfonate
0 ImagesCat. No.: HY-130112CAS No.: 690632-55-4Synonyms: NHS-C4-MTSN-Succinimidyloxycarbonylpropyl methanethiosulfonate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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PDB-Pfp
0 ImagesCat. No.: HY-129366CAS No.: 2088570-81-2PDB-Pfp is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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THP-SS-PEG1-Tos
0 ImagesCat. No.: HY-140124CAS No.: 1807512-37-3THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Alkyne-PEG4-SS-PEG4-alkyne
0 ImagesCat. No.: HY-135970Alkyne-PEG4-SS-PEG4-alkyne is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Alkyne-PEG4-SS-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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SS-bis-amino-PEG4-NHS ester
0 ImagesCat. No.: HY-136134SS-bis-amino-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Azidoethyl-SS-propionic acid
0 ImagesCat. No.: HY-140100CAS No.: 2228857-32-5Azidoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azidoethyl-SS-propionic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-amino-PEG3-SSPy
0 ImagesCat. No.: HY-136041CAS No.: 2740153-37-9Boc-amino-PEG3-SSPy is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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OPSS-Val-Cit-PAB-PNP
0 ImagesCat. No.: HY-141145CAS No.: 3047198-18-2OPSS-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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NO2-SPDB-sulfo
0 ImagesCat. No.: HY-133548CAS No.: 663598-89-8NO2-SPDB-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Py-ds-dmBut-amido-PEG4-NHS ester
0 ImagesCat. No.: HY-136157CAS No.: 3029934-62-8Py-ds-dmBut-amido-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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THP-SS-PEG1-Boc
0 ImagesCat. No.: HY-140123CAS No.: 1807503-88-3THP-SS-PEG1-Boc is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Acid-PEG3-SS-PEG3-acid
0 ImagesCat. No.: HY-140113CAS No.: 2055014-98-5Acid-PEG3-SS-PEG3-acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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SPDMV-sulfo
0 ImagesCat. No.: HY-129373CAS No.: 2101206-86-2SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
