Adenosine Receptor
P1 receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
Adenosine Receptor Isoform Specific Products
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Adenosine Receptor Inhibitors
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Adenosine Receptor Agonists
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Adenosine Receptor Antagonists
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Adenosine Receptor Activators
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Adenosine Receptor Modulators
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Adenosine Receptor Degrader
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Adenosine Receptor Ligands
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Adenosine Receptor Related Products (428)
Related Products (428)
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Antibodies (2)
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Adenosine Receptor Isoform Comparison
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Derenofylline (Standard)
0 ImagesCat. No.: HY-14858RCAS No.: 251945-92-3Synonyms: SLV 320 (Standard)Derenofylline (Standard) is the analytical standard of Derenofylline. This product is intended for research and analytical applications. Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.
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MRS1220 (Standard)
0 ImagesCat. No.: HY-103190RCAS No.: 183721-15-5MRS1220 (Standard) is the analytical standard of MRS1220 (HY-103190). This product is intended for research and analytical applications. MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo.
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N-[(4-Aminophenyl)methyl]adenosine (Standard)
![N-[(4-Aminophenyl)methyl]adenosine (Standard)](https://file.medchemexpress.com/product_pic/hy-100130r.gif "Click to View N-[(4-Aminophenyl)methyl]adenosine (Standard) Product Detail")
0 ImagesCat. No.: HY-100130RCAS No.: 95523-13-0N-[(4-Aminophenyl)methyl]adenosine (Standard) is the analytical standard of N-[(4-Aminophenyl)methyl]adenosine (HY-100130). This product is intended for research and analytical applications. 0
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(±)-5'-Chloro-5'-deoxy-ENBA
0 ImagesCat. No.: HY-103163CAS No.: 103626-26-2(±)-5'-Chloro-5'-deoxy-ENBA is an agonist of A1AR. (±)-5'-Chloro-5'-deoxy-ENBA produces hypothermia in mice.
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8-Bromotheophylline (Standard)
0 Images8-Bromotheophylline (Standard) is the analytical standard of 8-Bromotheophylline. This product is intended for research and analytical applications. 8-Bromotheophylline can be used for the synthesis of the Oxazolo[2,3-f]purinediones, which are evaluated for their affinity at adenosine A1 and A2A receptors.
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N6-Ethyladenosine (Standard)
0 ImagesCat. No.: HY-111809RCAS No.: 14357-08-5N6-Ethyladenosine (Standard) is the analytical standard of N6-Ethyladenosine (HY-111809). This product is intended for research and analytical applications. N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively.
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Ciforadenant (Standard)
0 ImagesSynonyms: CPI-444 (Standard); V81444 (Standard)Ciforadenant (Standard) is the analytical standard of Ciforadenant (HY-101978). This product is intended for research and analytical applications. Ciforadenant (CPI-444) is a potent, orally active and selective adenosine A2A receptor (A2AR) antagonist, which induces antitumor responses.
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Imaradenant (Standard)
0 ImagesCat. No.: HY-101980RCAS No.: 1321514-06-0Synonyms: HTL1071 (Standard); AZD4635 (Standard)Imaradenant (Standard) is the analytical standard of Imaradenant (HY-101980). This product is intended for research and analytical applications. AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors.
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DPCPX-d4
0 ImagesCat. No.: HY-100937SSynonyms: PD 116948-d4
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Xanthine amine congener trihydrochloride
0 ImagesCat. No.: HY-101139BCAS No.: 2459963-12-1Synonyms: XAC trihydrochlorideXanthine amine congener trihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2?receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model.
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L-97-1
0 ImagesCat. No.: HY-136702CAS No.: 770703-20-3L-97-1 is a A1 adenosine receptor (A1AR) antagonist. L-97-1 is a water-soluble small molecule compound with high affinity and high selectivity against human A1 adenosine receptors. L-97-1 works by blocking A1 adenosine receptors. In patients with asthma, adenosine is an important signaling molecule capable of causing bronchoconstriction by activating A1AR. L-97-1 reduces airway hyperreactivity (BHR) by competitively binding to A1AR, thereby alleviating or blocking adenosine-induced bronchoconstriction and inflammation.
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PSB-1115 (Standard)
0 ImagesPSB-1115 (Standard) is the analytical standard of PSB-1115. This product is intended for research and analytical applications. PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).
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Acefylline (Standard)
0 ImagesSynonyms: Theophyllineacetic acid (Standard); Theophylline-7-acetic acid (Standard)Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505). This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research.
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ANR94 (Standard)
0 ImagesCat. No.: HY-103162RCAS No.: 634924-89-3ANR94 (Standard) is the analytical standard of ANR94 (HY-103162). This product is intended for research and analytical applications. ANR94 is a potent and selective adenosine A2A receptor (AA2AR) antagonist with an Ki of 46 nM for hAA2AR. ANR94 has the potential for the research of Parkinson's disease.
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LUF5831
0 ImagesCat. No.: HY-116837CAS No.: 333963-57-8LUF5831 is a non-adenosine agonist with an affinity of Ki=18 nM for adenosine A1 receptor.
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N6-Benzyladenosine (Standard)
0 ImagesN6-Benzyladenosine (Standard) (Benzyladenosine (Standard)) is the analytical standard of N6-Benzyladenosine (HY-N7844). This product is intended for research and analytical applications. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma-.
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LUF 5608
0 ImagesCat. No.: HY-129463CAS No.: 674289-28-2LUF 5608 is a ligand that exhibits high adenosine A1 affinity of 7.7 nM.
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PD 117519 (Standard)
0 ImagesCat. No.: HY-100032RCAS No.: 96392-15-3Synonyms: CI947 (Standard)
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MRS 1523 (Standard)
0 ImagesCat. No.: HY-121119RCAS No.: 212329-37-8MRS 1523 (Standard) is the analytical standard of MRS 1523. This product is intended for research and analytical applications. MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons.
