Adenosine Receptor
P1 receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
Adenosine Receptor Isoform Specific Products
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Adenosine Receptor Inhibitors
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Adenosine Receptor Agonists
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Adenosine Receptor Antagonists
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Adenosine Receptor Activators
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Adenosine Receptor Modulators
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Adenosine Receptor Degrader
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Adenosine Receptor Ligands
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Adenosine Receptor Related Products (428)
Related Products (428)
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Antibodies (2)
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Adenosine Receptor Isoform Comparison
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FSCPX
0 ImagesFSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.
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Adenosine receptor antagonist 1
0 ImagesCat. No.: HY-141865CAS No.: 2682930-40-9Adenosine receptor antagonist 1 is a A2aR-selective antagonist with an IC50 of 0.29 nM and displays 14-fold more selective for A2aR than A2bR.
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JNJ-10450232
0 ImagesCat. No.: HY-182783CAS No.: 862248-40-6Synonyms: NTM-006NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain.
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FK 838
0 ImagesCat. No.: HY-105227CAS No.: 131185-37-0FK 838 is an adenosine subtype-1 receptor antagonist with potent diuretic activity. FK 838 can be used for the research of cardiovascular disease, such as hypertension .
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N 0861
0 ImagesCat. No.: HY-105093CAS No.: 141696-90-4N-0861 is a novel selective A1 adenosine receptor antagonist. In studies, it has been shown to be able to inhibit the negative conduction effects (prolonged AH interval) and chest pain caused by adenosine, while having no significant effect on the increase in coronary blood flow velocity caused by adenosine. This indicates that N-0861 has the property of selectively inhibiting A1 adenosine receptors.
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VUF8507
0 ImagesCat. No.: HY-120487CAS No.: 112575-48-1VUF8507 is an allosteric modulator for adenosine A3 receptor with a Ki of 204 nM.
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Cirazoline hydrochloride (Standard)
0 ImagesCat. No.: HY-101300RCAS No.: 40600-13-3Synonyms: LD 3098 hydrochloride (Standard)Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).
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CV1808 (Standard)
0 ImagesCat. No.: HY-103183RCAS No.: 53296-10-9Synonyms: 2-Phenylaminoadenosine (Standard)CV1808 (Standard) is the analytical standard of CV1808. This product is intended for research and analytical applications. CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.
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CVT-2759
0 ImagesCat. No.: HY-123196CAS No.: 342419-09-4CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation.
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(Rac)-WRC-0571
0 ImagesCat. No.: HY-118444CAS No.: 501667-77-2(Rac)-WRC-0571 is a highly potent, orally active and selective, non-xanthine antagonist of A1 adenosine receptors. (Rac)-WRC-0571 inhibits [3H]-N6-cyclohexyladenosine (CHA) binding to guinea pig A1-receptors with a Ki value of 1.1 nM.
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Norisoboldine (Standard)
0 ImagesCat. No.: HY-N0586RCAS No.: 23599-69-1Synonyms: (+)-Laurelliptine (Standard)Norisoboldine (Standard) is the analytical standard of Norisoboldine. This product is intended for research and analytical applications. Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.
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KF26777 free base
0 ImagesCat. No.: HY-119191CAS No.: 206129-88-6KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.
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Regadenoson (Standard)
0 ImagesSynonyms: CVT-3146 (Standard)Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS.
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Doxofylline-d4
0 ImagesCat. No.: HY-B0004S1CAS No.: 1346599-13-0Doxofylline-d4 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.
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8-Cyclopentyl-1,3-dimethylxanthine (Standard)
0 ImagesCat. No.: HY-W011955RCAS No.: 35873-49-58-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.
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Ap2A disodium
0 ImagesCat. No.: HY-134367CAS No.: 85065-24-3Ap2A (disodium) is a symmetrical dinucleoside polyphosphate. Ap2A (disodium) can promote the growth of vascular smooth muscle cells.
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I-AB-MECA
0 ImagesCat. No.: HY-124259CAS No.: 152918-27-9I-AB-MECA is an important radioligand for the study of A3 adenosine receptors (A3AR).
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LUF6096 (Standard)
0 ImagesCat. No.: HY-10915RCAS No.: 1116652-18-6LUF6096 (Standard) is the analytical standard of LUF6096 (HY-10915). This product is intended for research and analytical applications. LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury.
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MRS-1191 (Standard)
0 ImagesMRS-1191 (Standard) is the analytical standard of MRS-1191. This product is intended for research and analytical applications. MRS-1191 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells. MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
