Adenylate Cyclase
Adenylyl cyclase
Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.
Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.
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Adenylate Cyclase Inhibitors
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Adenylate Cyclase Agonists
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Adenylate Cyclase Antagonists
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Adenylate Cyclase Activators
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Adenylate Cyclase Modulators
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Adenylate Cyclase Control
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Adenylate Cyclase Ligand
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Adenylate Cyclase Related Products (106)
Related Products (106)
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Antibodies (2)
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BPIPP
0 ImagesBPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research.
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Albanin A
0 ImagesCat. No.: HY-N10772CAS No.: 73343-42-7Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.
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SKF-83566 hydrobromide
0 ImagesCat. No.: HY-103430CAS No.: 108179-91-5SKF-83566 hydrobromide is an orally active, blood-brain barrier-permeable D1/D5 dopamine receptor antagonist with a Ki value of approximately 0.4-0.56 nM. SKF-83566 hydrobromide modulates locomotor behavior and spatial memory by blocking D1 receptors and inhibits glioblastoma progression by targeting the DRD1/c-Myc/UHRF1 pathway. SKF-83566 hydrobromide acts as an inhibitor of the dopamine transporter (DAT) and adenylyl cyclase 2 (AC2). SKF-83566 hydrobromide competitively binds to DAT to inhibit dopamine reuptake and non-competitively inhibits AC2 activity, thereby reducing cAMP accumulation. SKF-83566 hydrobromide is used in research areas such as dopaminergic system mechanisms, learning and memory, targeted intervention for glioblastoma, AC2 pathophysiology, antiparasitic drug screening, and synaptic plasticity (the "gating effect").
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Mant-GTPγS triammonium
0 ImagesCat. No.: HY-115748AMant-GTPγS triammonium, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS triammonium is a potent YdeH inhibitor.
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Small Cardioactive Peptide B (SCPB)
0 ImagesSmall Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
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2-Chloro-ADP sodium solution (10 mM)
0 ImagesCat. No.: HY-131776ACAS No.: 82927-78-4Synonyms: 2-Chloroadenosine 5′-diphosphate sodium solution (10 mM)2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium (10 mM) is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase. 2-Chloro-ADP sodium (10 mM) inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM.
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SQ22536 (Standard)
0 ImagesSQ22536 (Standard) is the analytical standard of SQ22536. This product is intended for research and analytical applications. SQ22536 is an effective adenylate cyclase (AC) inhibitor.
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Forskolin (GMP)
0 ImagesCat. No.: HY-15371GCAS No.: 66575-29-9Synonyms: Coleonol (GMP); Colforsin (GMP); HL 362 (GMP)Forskolin (Coleonol) (GMP) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin (GMP) is also an inducer of intracellular cAMP formation. Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy.
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AC10142A
0 ImagesCat. No.: HY-169263CAS No.: 2963581-29-3AC10142A is a selective Adenylyl Cyclase Type 1 inhibitor with IC50 of 0.26 μM. AC10142A can be used to study pain models.
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DMP 904
0 ImagesCat. No.: HY-12132CAS No.: 202579-74-6DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity.
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VHC-7
0 ImagesCat. No.: HY-130629CAS No.: 14750-21-1VHC-7 is a potent and selective adenylyl cyclase type 8 (AC8) agonist, with an EC50 value of 105.2 nM. VHC-7 increases cyclic adenosine monophosphate (cAMP) levels. VHC-7 can be used for the study of central nervous system disorders and heart diseases.
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CCPA hemihydrate
0 ImagesCat. No.: HY-103185ACAS No.: 1217443-91-8Synonyms: 2-Chloro-N6-cyclopentyladenosine hemihydrateCCPA (2-Chloro-N6-cyclopentyladenosine) hemihydrate a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA hemihydrate inhibits adenylate cyclase with an IC50 of 33 nM. CCPA hemihydrate exhibits anti-seizure and cardiacprotective activity. CCPA hemihydrate can be used for the research of seizure and myocardial infarction.
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L 858051 dihydrochloride
0 ImagesCat. No.: HY-116540ACAS No.: 115116-37-5Synonyms: 7DMB-ForskolinL 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg2+-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca2+ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes.
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L 858051
0 ImagesCat. No.: HY-116540CAS No.: 110452-75-0Synonyms: 7DMB-Forskolin free baseL 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg2+-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca2+ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes.
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Glycerophosphoinositol 4-phosphate disodium
0 ImagesCat. No.: HY-171909ASynonyms: GroPIns-4-P disodiumGlycerophosphoinositol 4-phosphate (GroPIns-4-P) disodium is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate disodium can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate disodium can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate disodium can be used in research on cancer cell motility and invasiveness.
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Helodormin
0 ImagesCat. No.: HY-P2702CAS No.: 89468-62-2Helodormin is a VIP-secretin-like peptide isolated from the venom of the Mexican monster lizard (Heloderma suspectum). Helodormin affects a variety of cellular functions by modulating intracellular signaling through activation of adenylate cyclase. Helodormin can be used to study the evolution and function of the secretin and VIP peptide families.
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cGAS-IN-9
0 ImagesCat. No.: HY-147129CAS No.: 2369750-66-1cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) inhibitor, with IC50 values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase, with an IC50 of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10, as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases.
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CB-6673567
0 ImagesCat. No.: HY-101863CAS No.: 379218-90-3CB-6673567 is a selective AC1 inhibitor with an IC50 of 77 μM .CB-6673567blocks the choline-induced cAMP increase and can be used for cardiovascular diseases research.
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MY-1250
0 ImagesCat. No.: HY-129272CAS No.: 63768-47-8MY-1250 is a histamine release inhibitor. MY-1250 is the major active metabolite of Repirinast (HY-109544). MY-1250 stimulates adenylate cyclase to increase intracellular cyclic adenosine monophosphate levels, reduce intracellular ATP levels, inhibit antigen-induced intracellular calcium store mobilization, and induce phosphorylation of the 78 kDa protein. MY-1250 inhibits antigen- and phospholipase A2-induced release of histamine and slow-reacting substance of anaphylaxis from mast cells, lung tissue fragments and basophils. MY-1250 can be used in research related to allergic diseases and bronchial asthma.
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(+)-Eseroline
0 ImagesCat. No.: HY-W387210CAS No.: 29347-15-7(+)-Eseroline is an opioid agonist and adenylate cyclase inhibitor (Ki=6-8 μM). (+)-Eseroline binds specifically to μ-opioid receptors and δ-opioid receptors on rat brain cell membranes (Ka=0.7 μM). (+)-Eseroline exhibits only weak activity in various mouse analgesic models and can be used for studies on pain-related mechanisms.
