202579-74-6
202579-74-6
Chemical Structure
DMP 904
- CAS No.: 202579-74-6
- Formula:C21H28N4O
- Molecular Weight:352.47
IUPAC Name: 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
InChIKey: QBBJSFUFEUXTNU-UHFFFAOYSA-N
SMILES: CC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1
Biological Activity: DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity[1][2].
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DMP 904 | DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity. | |||||||||||||||||||||
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References
- [1]. Li YW, et al. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11(1):21-52. [Content Brief]
- [2]. Nielsen DM, et al. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004 Sep 19;499(1-2):135-46. [Content Brief]
