AT2 Receptor
References:
- [1]. Abadir PM, et al. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension. 2003 Oct;42(4):600-4. [Content Brief]
- [2]. Tsutsumi Y, et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest. 1999 Oct;104(7):925-35. [Content Brief]
- [3]. Wang G, et al. Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. Am J Physiol Regul Integr Comp Physiol. 2012 May;302(9):R1076-83. [Content Brief]
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AT2 Receptor Related Products (30)
Related Products (30)
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Novokinin TFA
0 ImagesCat. No.: HY-P0080ACAS No.: 1262750-59-3Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor.
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DMP 811
0 ImagesCat. No.: HY-180401CAS No.: 139964-19-5DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension.
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L-162537
0 ImagesCat. No.: HY-108120CAS No.: 167027-99-8L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension.
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GA-0056
0 ImagesCat. No.: HY-19207CAS No.: 153465-66-8GA-0056 is an angiotensin II receptor blocker. GA-0056 can be used in the research of heart disease.
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L-163958
0 ImagesCat. No.: HY-114284CAS No.: 168473-51-6L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases.
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TA-606
0 ImagesCat. No.: HY-123226CAS No.: 190602-72-3TA-606 is a potent and orally active angiotensin II-receptor antagonist. TA-606 shows antihypertensive efficacy. TA-606 can be used for hypertension research.
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rac-Olodanrigan
0 ImagesCat. No.: HY-19202CAS No.: 152362-51-1Synonyms: rac-EMA401; rac-PD-126055; EMA400rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.
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S 8308
0 ImagesCat. No.: HY-117876CAS No.: 119256-78-9Synonyms: CV 2961S 8308 (CV 2961) is a non-peptide angiotensin II (Angiotensin II receptor) receptor antagonist with transient oral activity and short-acting intravenous activity, and exhibits an IC50 of 15 μM in rats. S 8308 competitively blocks the binding of angiotensin II to its receptor, thereby inhibiting vasoconstriction and pressor responses. S 8308 can be used in the research of hypertension and renal hypertension.
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CL-329167
0 ImagesCat. No.: HY-117858CAS No.: 143945-39-5CL-329167 (compound 12) is an orally active and competitive angiotensin II receptor antagonist (IC50=6 nM). CL-329167 can be used in the research of hypertension.
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