139964-19-5
139964-19-5
Chemical Structure
DMP 811
- CAS No.: 139964-19-5
- Formula:C23H24N6O2
- Molecular Weight:416.49
IUPAC Name: 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-ethyl-2-propyl-1H-imidazole-5-carboxylic acid
InChIKey: OFYWYKMCRWMPPQ-UHFFFAOYSA-N
SMILES: O=C(O)C1=C(N=C(N1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCC)CC
Biological Activity: DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension[1][2][3].
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DMP 811 | DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension. | |||||||||||||||||||||
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References
- [1]. Wong PC, et al. Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811. Clin Exp Hypertens. 1995;17(8):1233-1256. [Content Brief]
- [2]. David J C, et al. Nonpeptide angiotensin II receptor antagonists: the discovery of DMP 581 and DMP 811. Bioorganic & Medicinal Chemistry Letters. Volume 4, Issue 1, 6 January 1994, Pages 63-68.
- [3]. Agra AM, et al. High-performance liquid chromatographic determination of a potent AII receptor antagonist (DMP 811) in plasma. J Chromatogr. 1993 Oct 29;620(2):205-9. [Content Brief]
