Signaling Pathway

CRTH2 (GPR44)

CRTH2 (GPR44)

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CRTH2 (GPR44) Inhibitors & Modulators (2)

Product Name Catalog No. Brief Description
AZD1981

HY-15950

AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).

Fevipiprant

HY-16768

Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.