1. Signaling Pathways
  2. CRTH2 (GPR44)


DP2 receptor; Prostaglandin DP2 receptor

Chemoattractant receptor homologous molecule of Th2 cells (CRTH2) has been shown to mediate the chemotaxis of eosinophils, basophils and Th2-type T lymphocytes. The major mast cell product prostaglandin (PG) D(2) is considered to be the principal ligand of CRTH2.

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. CRTh2 receptors, expressed on eosinophils, basophils, T-helper 2 cells, macrophages, and neutrophils are known to be involved in chemotaxis and activation of these cells, which form the key events initiating the inflammatory response in allergic diseases.

CRTH2 (GPR44) Related Products (0):

Cat. No. Product Name Effect Purity