CaMK
Calmodulin-dependent protein kinases; Calmodulin-dependent kinases
The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.
CaMK II is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.
Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the CaMKs which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.
CaMK Isoform Specific Products
All Product Categories
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CaMK Related Products (124)
Related Products (124)
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Antibodies (7)
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CaMK Isoform Comparison
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Prenylamine lactate
0 ImagesPrenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents.
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STO-609 (Standard)
0 ImagesCat. No.: HY-19805RCAS No.: 52029-86-4STO-609 (Standard) is the analytical standard of STO-609 (HY-19805). This product is intended for research and analytical applications. STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein Kinase Kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein Kinase Kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
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KN-93 (Standard)
0 ImagesCat. No.: HY-15465RCAS No.: 139298-40-1
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CaMKII-IN-4
0 ImagesCat. No.: HY-183131CAS No.: 1026029-03-7CaMKII-IN-4 is a pyrimidine-based ATP-competitive CaMKIIδ inhibitor with an enzymatic IC50 of >20 μM.
