CaMK Ligand

PTCA is a potent Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) ligand with a pK_i value of 7.2.

Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na⁺/K⁺-ATPase, Ca²⁺-ATPase and Mg²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme.

CaMKIIα ligand-1 is a photoactivatable CaMKIIα ligand that can be used for PROTAC synthesis. CaMKIIα ligand-1 serves as the target protein ligand for CaMKIIα-PHOTAC (HY-156104). CaMKIIα ligand-1 is applicable to research related to neurological diseases.

eEF2K ligand-1 is a PROTAC target protein ligand that targets eEF2K, and it is applicable to research related to PROTAC synthesis. eEF2K ligand-1 serves as the target protein of PROTAC eEF2K degrader-1 (HY-146324).

TRIB2 ligand-1 is a ligand of TRIB2 (Ligands for Target Protein for PROTACs). TRIB2 ligand-1 can be used for synthesis PROTAC TRIB2 degrader-1 (HY-168274).