Dopamine Receptor
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.
Dopamine Receptor Isoform Specific Products
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Dopamine Receptor Inhibitors
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Dopamine Receptor Agonists
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Dopamine Receptor Antagonists
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Dopamine Receptor Activators
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Dopamine Receptor Modulators
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Dopamine Receptor Chemical
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Dopamine Receptor MDM2 Inhibitor
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Dopamine Receptor Controls
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Dopamine Receptor Ligands
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Dopamine Receptor Related Products (1078)
Related Products (1078)
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Antibodies (7)
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Related Compound Screening Libraries (1)
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Dopamine Receptor Isoform Comparison
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Vanicoside E
0 ImagesCat. No.: HY-N10950CAS No.: 208707-91-9
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BRL 34778
0 ImagesCat. No.: HY-106820CAS No.: 86580-77-0BRL 34778 is a potent, selective and orally active dopamine D2 receptor antagonist with a Ki of 2.14 nM. BRL 34778 exhibits antipsychotic activity with low activity for extrapyramidal effects and sedation. BRL 34778 can be used for the research of neurological disease, such as schizophrenia.
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Itopride-d4
0 ImagesCat. No.: HY-B0732AS1Synonyms: HSR803-d4 free baseItopride-d4 (HSR803-d4 free base) is the deuterium labeled Itopride (HY-B0732A). Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)
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Zelandopam anhydrous
0 ImagesCat. No.: HY-106889ACAS No.: 138086-00-7Synonyms: YM435 anhydrous
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Isoremoxipride
0 ImagesCat. No.: HY-W647997CAS No.: 107188-74-9Isoremoxipride is a dopamine antagonist. Isoremoxipride is a 3-methoxy isomer that exhibits affinities for the dopamine D2 receptor.
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D4R antagonist-1
0 ImagesCat. No.: HY-145905CAS No.: 2846077-19-6D4R antagonist-1 is a potent and selective D4R antagonist with an IC50 of 6.87 µM. D4R antagonist-1 has the potential for the research of Parkinson’s disease.
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Bromperidol decanoate (Standard)
0 ImagesCat. No.: HY-118551RCAS No.: 75067-66-2Synonyms: R46541 (Standard)Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.
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rel-Quinpirole dihydrochloride
0 ImagesCat. No.: HY-122495CAS No.: 73625-62-4Synonyms: rel-LY 171555 dihydrochloride; rel-LY 141865 dihydrochloriderel-Quinpirole (rel-LY 171555) dihydrochloride, an ergot compound, is a selective dopamine (DA) D2 receptor agonist. rel-Quinpirole dihydrochloride can be used for research on neurological diseases.
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AJ-76
0 ImagesCat. No.: HY-111283CAS No.: 85379-09-5Synonyms: (+)-AJ 76; (1S,2R)-AJ 76AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor.
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(±)-Butaclamol
0 ImagesCat. No.: HY-165622CAS No.: 36504-93-5Synonyms: AY-23,028 free base; dl-Butaclamol(±)-Butaclamol is a antipsychotic agent and act as a D2 receptor antagonist.
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Tefludazine
0 ImagesCat. No.: HY-184802CAS No.: 80273-79-6Tefludazine is an orally active antagonist of dopamine D2 receptor with an IC50 of 8.8 nM and 5-HT2 receptor with an IC50 of 8.6 nM. Tefludazine moderately inhibits the uptake of dopamine, norepinephrine and serotonin in rat brain synaptosomes, with IC50 values of 520 nM, 660 nM and 7000 nM, respectively. Tefludazine exhibits long-acting antipsychotic activity, lacks anticholinergic activity, shows Clozapine (HY-14539)-like effects at low doses and Haloperidol (HY-14538)-like effects at high doses. Tefludazine can be used for the research of psychotic disorders.
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(+)-Razpipadon
0 ImagesCat. No.: HY-141495BCAS No.: 1643489-51-3Synonyms: (+)-PW0464(+)-Razpipadon ((+)-PW0464) is a selective D1 dopamine receptor agonist belonging to non-catechol compounds. (+)-Razpipadon activates the G protein pathway, while restricting β-arrestin coupling through the proximity effect of fluoromethyl-TM5, thereby achieving specific regulation of downstream pathways. (+)-Razpipadon can be used in studies related to Parkinson's disease.
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Thioridazine (Standard)
0 ImagesThioridazine (Standard) is the analytical standard of Thioridazine. This product is intended for research and analytical applications. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).
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MPTP hydrochloride (Standard)
0 ImagesIproniazid (phosphate) (Standard) is the analytical standard of Iproniazid (phosphate). This product is intended for research and analytical applications. Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity.
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VK-28
0 ImagesCat. No.: HY-W686216CAS No.: 312611-92-0VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease.
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Lergotrile
0 ImagesCat. No.: HY-107002CAS No.: 36945-03-6Lergotrile is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile has the potential for the research of Parkinson's disease.
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CI-943
0 ImagesCat. No.: HY-100161CAS No.: 89239-35-0Synonyms: (±)-CI-943CI-943 is a potential antipsychotic agent.
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N-Desmethyl xanomeline
0 ImagesCat. No.: HY-181425CAS No.: 131986-96-4N-Desmethyl xanomeline is a pharmacologically active metabolite of Xanomeline (HY-105182). N-Desmethyl xanomeline binds to muscarinic, serotonergic, histaminergic and dopaminergic receptors. N-Desmethyl xanomeline can be used for the research of schizophrenia.
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Piquindone
0 ImagesCat. No.: HY-105903CAS No.: 78541-97-6Synonyms: Ro 22-1319Piquindone (Ro 22-1319) is a potent antipsychotic agent. Piquindone binds to a D2 dopaminergic receptor subtype in a sodium-dependent manner. Piquindone can be used in the research of schizophrenia.
