23007-85-4
23007-85-4
Chemical Structure
MPTP hydrochloride
- CAS No.: 23007-85-4
- Formula:C12H16ClN
- Molecular Weight:209.72
IUPAC Name: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
InChIKey: KOWJANGMTAZWDT-UHFFFAOYSA-N
SMILES: CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl
Biological Activity: MPTP hydrochloride is a brain penetrant dopaminergic neurotoxin. MPTP hydrochloride can be used to induce Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. MPTP hydrochloride has been verified by MCE with professional biological experiments.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MPTP hydrochloride | 99.91% | MPTP hydrochloride is a brain penetrant dopaminergic neurotoxin. MPTP hydrochloride can be used to induce Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis. MPTP hydrochloride has been verified by MCE with professional biological experiments. | ||||||||||||||||||||
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MPTP hydrochloride (Standard) | ≥98% | Iproniazid (phosphate) (Standard) is the analytical standard of Iproniazid (phosphate). This product is intended for research and analytical applications. Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity. | ||||||||||||||||||||
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References
- [1]. Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12. [Content Brief]
- [2]. Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83. [Content Brief]
- [3]. Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180. [Content Brief]
