36504-93-5
Chemical Structure
(±)-Butaclamol
Synonym(s): AY-23,028 free base; dl-Butaclamol
- CAS No.: 36504-93-5
- Formula:C25H31NO
- Molecular Weight:361.52
InChIKey: ZZJYIKPMDIWRSN-TZBSWOFLSA-N
SMILES: CC(C)([C@@]1(C[C@]2([H])C3=CC=CC4=C3[C@@](CN2CC1)([H])C5=CC=CC=C5CC4)O)C
Biological Activity: (±)-Butaclamol (AY-23,028 free base; dl-Butaclamol) is the racemate of Butaclamol. Butaclamol is an orally active neuroleptic and a dopamine receptor antagonist. Butaclamol specifically blocks postsynaptic dopamine receptors and antagonizes dopaminergic neurotransmission, thereby exerting antipsychotic effects, and has very weak adrenergic receptor blocking activity. Butaclamol can be used in research on schizophrenia[1][2][3][4].
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(±)-Butaclamol | (±)-Butaclamol (AY-23,028 free base; dl-Butaclamol) is the racemate of Butaclamol. Butaclamol is an orally active neuroleptic and a dopamine receptor antagonist. Butaclamol specifically blocks postsynaptic dopamine receptors and antagonizes dopaminergic neurotransmission, thereby exerting antipsychotic effects, and has very weak adrenergic receptor blocking activity. Butaclamol can be used in research on schizophrenia. | |||||||||||||||||||||
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References
- [1]. Voith K, et al. The behavioral pharmacology of butaclamol hydrochloride (AY-23,028), a new potent neuroleptic drug. Psychopharmacologia. 1975 Apr 30;42(1):11-20. [Content Brief]
- [2]. Yokel RA, et al. Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology. 1976 Aug 17;48(3):311-8.
- [3]. Yokel RA, et al. Amphetamine- type reinforcement by dopaminergic agonists in the rat. Psychopharmacology (Berl). 1978 Jul 19;58(3):289-96.
- [4]. Lippmann W, et al. The effects of butaclamol hydrochloride, a new neuroleptic drug, on catecholamine turnover. Pharmacol Res Commun. 1975;7(4):371-85.
