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Cat. No.: HY-145905

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D4R antagonist-1

D4R antagonist-1 is a potent and selective D4R antagonist with an IC₅₀ of 6.87 µM. D4R antagonist-1 has the potential for the research of Parkinson’s disease.

For research use only. We do not sell to patients.

CAS No.: 2846077-19-6
Formula: C₂₁H₂₅F₂NO₂
Molecular Weight:361.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

D4R antagonist-1 Chemical Structure

CAS No.: 2846077-19-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

D4R antagonist-1 is a potent and selective D4R antagonist with an IC₅₀ of 6.87 µM. D4R antagonist-1 has the potential for the research of Parkinson’s disease^[1].

IC₅₀ & Target

D₄ Receptor

6.87 μM (IC₅₀)

All Dopamine Receptor Isoforms :

In Vitro

D4R antagonist-1 (compound 8c) shows good activity with an K_i of 135 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2846077-19-6
Molecular Weight 361.43
Formula C₂₁H₂₅F₂NO₂
SMILES

COC1=CC=C(C=C1F)CN2CCC[C@@H](C2)OCC3=CC(C)=C(C=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tolentino KT,et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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