Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2741)
Related Products (2741)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Chrysophanol dimethyl ether
0 ImagesCat. No.: HY-N17385CAS No.: 71013-35-9Chrysophanol dimethyl ether is an anthraquinone-type natural product. Chrysophanol dimethyl ether acts as a bioavailability enhancer for antibacterial and antifungal antibiotics. Chrysophanol dimethyl ether serves as a chemical marker for differentiating raw and processed medicinal Rheum palmatum, with lower signal intensity detected in raw samples and higher signal intensity in processed samples. Chrysophanol dimethyl ether is applicable to research related to bacterial and fungal infections.
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Hsp90-IN-47
0 ImagesCat. No.: HY-186076CAS No.: 958888-13-6Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer.
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Aegeline (Standard)
0 ImagesAegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity.
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Sikokianin A
0 ImagesCat. No.: HY-N10095CAS No.: 106293-99-6Synonyms: 4′-O-Demethylchamaejasmenin BSikokianin A is a biflavanone that can be isolated from the root of Stellera chamaejasme. Sikokianin A has antimitotic and antifungal activity to against Pyricularia oryzae.
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Terbinafine lactate
0 ImagesCat. No.: HY-17395BCAS No.: 335276-86-3Synonyms: TDT 067 lactateTerbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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L-Diguluronic acid disodium
0 ImagesL-Diguluronic acid disodium is a linear polysaccharide copolymer composed of two L-guluronic acid. L-Diguluronic acid disodium can be used to form Alginate. L-Diguluronic acid disodium is a generic name of unbranched polyanionic polysaccharides and it can be used for the research of antifungal agents delivery carries.
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Neryl arabinofuranosyl-glucoside
0 ImagesCat. No.: HY-N17265CAS No.: 84534-32-7Synonyms: Geranyl 1-O-α-L-arabinofuranosyl (1→6)-β-D-glucopyranosideNeryl arabinofuranosyl-glucoside (Geranyl 1-O-α-L-arabinofuranosyl (1→6)-β-D-glucopyranoside) is a terpene-derived glycoside. Neryl arabinofuranosyl-glucoside can be present in apricot fruits, melon stems and bitter melon stems. Neryl arabinofuranosyl-glucoside is negatively correlated with the bacterial genus Pseudomonas and the fungal genus Cladosporium, and positively correlated with unclassified fungi (unclassified_k__Fungi). Neryl arabinofuranosyl-glucoside can be used for studies on perinatal hypophosphatemia.
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VEGFR-2/DHFR-IN-1
0 ImagesCat. No.: HY-151458CAS No.: 2831498-15-6VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer.
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Anandamide-15N
0 ImagesCat. No.: HY-10863S2Purity: 99.78%Synonyms: AEA-15NN; Arachidonoyl ethanolamide-15NNAnandamide-15N (AEA-15N) is the 15N-labeled Anandamide (HY-10863). Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.
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Antifungal agent 55
0 ImagesCat. No.: HY-153620CAS No.: 2422019-80-3Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL.
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CDA-IN-3
0 ImagesCat. No.: HY-172523CAS No.: 932889-57-1CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .
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Antifungal agent 37
0 ImagesCat. No.: HY-151280CAS No.: 2833772-92-0Antifungal agent 37 is a geterocyclic disulfide, with antifungal activity.
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Geministatin D
0 ImagesCat. No.: HY-N20676CAS No.: 3131756-58-3Geministatin D is a derivative of Geministatin A that retains the C17 (Z,Z)-diene alkyl side chain but lacks the complete diester backbone. As a chemical degradation fragment of the parent compound, Geministatin D shows weak antibacterial activity against Gram-positive bacteria but exerts mild inhibitory effects on Saccharomyces cerevisiae. Geministatin D can be used in studies on fungal infections caused by Saccharomyces cerevisiae.
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Monocerin
0 ImagesCat. No.: HY-N6294CAS No.: 30270-60-1Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca.
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Hepcidin-20 (human)
0 ImagesCat. No.: HY-P4370CAS No.: 342790-23-2Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains.
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CZx-243
0 ImagesCat. No.: HY-187376CZx-243 is an orally active broad-spectrum antifungal agent. CZx-243 binds to the active site of fungal CYP51 and interferes with ergosterol biosynthesis by depleting ergosterol and causing the accumulation of upstream sterol intermediates. CZx-243 blocks yeast-to-hypha transition; it inhibits the membrane integrity of fungi such as Candida glabrata and Cryptococcus neoformans. CZx-243 significantly reduces renal fungal burden in a systemic mouse model of invasive fungal infection resistant to Fluconazole (HY-B0101). CZx-243 can be used in the research of fungal infections.
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Hunnemanine
0 ImagesHunnemanine is a protoberberine-type isoquinoline alkaloid with significant antifungal activity. At a concentration of 1000 ppm, Hunnemanine completely inhibits spore germination of a variety of phytopathogenic fungi, including Alternaria brassicae, Helminthosporium pennisetti, and Fusarium lini. Hunnemanine can be applied to studies on the infection mechanisms of phytopathogenic fungi and related control strategies.
