LPL Receptor
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LPL Receptor Related Products (204)
Related Products (204)
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BMS-960 free base
0 ImagesCat. No.: HY-120611CAS No.: 1265321-86-5BMS-960 free base is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
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S1P1 agonist 6
0 ImagesCat. No.: HY-156565CAS No.: 2433782-42-2S1P1 agonist 6 (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
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VPC12249
0 ImagesCat. No.: HY-129808CAS No.: 403520-23-0VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.
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Ozanimod-d6
0 ImagesCat. No.: HY-12288SSynonyms: RPC-1063-d6Ozanimod-d6 (RPC-1063-d6) is the deuterium labeled Ozanimod (HY-12288). Ozanimod (RPC-1063) is a CNS-penetrant sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS).
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Fingolimod phosphate (Standard)
0 ImagesCat. No.: HY-15381RCAS No.: 402615-91-2Synonyms: FTY720 phosphate (Standard)Fingolimod phosphate (Standard) is the analytical standard of Fingolimod phosphate. This product is intended for research and analytical applications. Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases.
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S1P1 agonist 7
0 ImagesCat. No.: HY-175984S1P1 agonist 7 is a potent, orally active, and β-arrestin-biased S1P1 agonist (EC50(G‑protein) = 12.7 nM and EC50(β‑arrestin) = 3.23 nM). S1P1 agonist 7 demonstrates potent immunomodulatory activity and a favorable safety profile. S1P1 agonist 7 exhibits excellent metabolic stability, minimal to moderate CYP inhibition, and S1P3-sparing selectivity. S1P1 agonist 7 shows pharmacokinetics, effectively reduces circulating lymphocytes, and significantly alleviates disease severity in experimental autoimmune encephalomyelitis (EAE) mouse models under both prophylactic and therapeutic regimens. S1P1 agonist 7 can be used for multiple sclerosis (MS) research.
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SLF80821178 hydrochloride
0 ImagesCat. No.: HY-162655ACAS No.: 2764877-62-3SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2), that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC50 of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice.
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W123
0 ImagesCat. No.: HY-116088CAS No.: 1345982-24-2W123, a FTY720 analog, is a competitive sphingosine 1-phosphate type 1 (S1P1) receptor antagonist. W123 is measured by GTPγS activation, MAPK recruitment, cell migration, and ligand-induced receptor internalization.
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SLF1081851 hydrochloride
0 ImagesCat. No.: HY-149004BCAS No.: 2999629-35-3SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system.
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ATX inhibitor 27
0 ImagesCat. No.: HY-173509CAS No.: 2023027-81-6ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer.
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SPL-IN-1
0 ImagesCat. No.: HY-163128CAS No.: 353770-24-8SPL-IN-1 (compound C17) is a dual species sphingosine-1-phosphate lyase inhibitor.
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BMS-986104
0 ImagesCat. No.: HY-120633CAS No.: 1622180-31-7BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC)-induced demyelination in a three-dimensional brain cell culture assay.
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GSK1842799
0 ImagesCat. No.: HY-16622CAS No.: 1005407-75-9GSK1842799 is an orally active selective S1P1 receptor agonist prodrug. GSK1842799 is promising for research of multiple sclerosis.
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SLB1122168 free base
0 ImagesCat. No.: HY-182375ACAS No.: 2764877-95-2SLB1122168 free base is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 free base inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 free base induces lymphopenia in circulating lymphocytes in mice and rats.
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S1PL-IN-
2
0 ImagesCat. No.: HY-124655CAS No.: 1897406-94-8S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis.
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RP-1859
0 ImagesCat. No.: HY-137973CAS No.: 1307869-95-9RP-1859 is a sphingosine 1-phosphate receptor (S1P) modulator. RP-1859 exerts anti-inflammatory and immunomodulatory activities. RP-1859 can be used for the research of iatrogenic autoimmune colitis.
