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Cat. No.: HY-129808

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VPC12249

VPC12249 is a competitive dual LPA1/LPA3 antagonist with K_i values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a K_i value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.

For research use only. We do not sell to patients.

CAS No.: 403520-23-0
Formula: C₃₄H₅₂NO₆P
Molecular Weight:601.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

VPC12249 Chemical Structure

CAS No.: 403520-23-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All LPL Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	>10000 nM Compound: 14a	In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines In vitro antagonism of LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 3 in HEK293T cell lines	[PMID: 15125924]
HEK-293T	IC₅₀	>10000 nM Compound: 14a	In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines In vitro ability to antagonize LPA-evoked [35S]GTP-gamma-S binding to lysophosphatidic acid receptor 1 in HEK293T cell lines	[PMID: 15125924]
HEK-293T	IC₅₀	5210 nM Compound: 20	Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells Antagonist activity at mouse LPA1 receptor transfected in HEK293T cells	10.1039/C4MD00333K
HEK-293T	IC₅₀	6450 nM Compound: 20	Antagonist activity at human LPA3 receptor transfected in HEK293T cells Antagonist activity at human LPA3 receptor transfected in HEK293T cells	10.1039/C4MD00333K

Chemical Information

CAS No. 403520-23-0
Molecular Weight 601.75
Formula C₃₄H₅₂NO₆P
SMILES

CCCCCCCC/C=C\CCCCCCCC(N[C@@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)COP(O)(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Heise CE, et al. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol. 2001 Dec;60(6):1173-80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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VPC12249

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VPC12249 Related Classifications

HY-129808 Related Classifications