Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (614)
Related Products (614)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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Dipyanone hydrochloride
0 ImagesCat. No.: HY-168816CAS No.: 102762-20-9Dipyanone hydrochloride is structurally similar to known opioids.
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Samidorphan (Standard)
0 ImagesCat. No.: HY-123689RCAS No.: 852626-89-2Synonyms: ALKS-33 (Standard); RDC-0313 (Standard)Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals.
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U-48520
0 ImagesCat. No.: HY-130367CAS No.: 67579-11-7U-48520 is an agonist for μ-opioid receptor with EC50 of 1561 nM.
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JTC-801 free base
0 ImagesCat. No.: HY-13274ACAS No.: 244218-93-7JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM.
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Bromadol
0 ImagesCat. No.: HY-119914CAS No.: 77239-98-6Bromadol is an opioid.
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Salvinorin A propionate
0 ImagesCat. No.: HY-137920CAS No.: 689295-71-4Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A propionate is a non-nitrogenous neoclerodane isolated from Salvia divinorum.
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LY2940094 (Standard)
0 ImagesSynonyms: BTRX-246040 (Standard)LY2940094 (Standard) is the analytical standard of LY2940094. This product is intended for research and analytical applications. LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.
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AH 7563
0 ImagesCat. No.: HY-W714505CAS No.: 63886-94-2AH 7563 structurally belongs to the opioid compounds and exhibits analgesic activity. In the phenylquinone test and hot plate test, the ED50 of AH 7563 for analgesia in mice were 15.3 mg/kg (orally) and 15.5 mg/kg (subcutaneous injection), respectively.
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CYM51010 (Standard)
0 ImagesCat. No.: HY-104006RCAS No.: 1069498-96-9CYM51010 (Standard) is the analytical standard of CYM51010 (HY-104006). This product is intended for research and analytical applications. CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC50 of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms.
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N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride
0 ImagesCat. No.: HY-168818CAS No.: 28456-30-6N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is structurally similar to known opioids.
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AT-127
0 ImagesCat. No.: HY-118987CAS No.: 2099680-72-3AT-127 is a NOP receptor partial agonist, stimulating NOP/G-protein interaction in a concentration dependent manner.
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3,4-Ethylenedioxy U-51754 hydrochloride
0 ImagesCat. No.: HY-158899CAS No.: 2748623-92-73,4-Ethylenedioxy U-51754 hydrochloride is structurally similar to known opioids.
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5′-Guanidinonaltrindole
0 ImagesCat. No.: HY-169822CAS No.: 219655-56-8Synonyms: GNTI5′-Guanidinonaltrindole (GNTI) is a selective kappa opioid receptor antagonist.
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SCH 221510 (Standard)
0 ImagesCat. No.: HY-107722RCAS No.: 322473-89-2SCH 221510 (Standard) is the analytical standard of SCH 221510 (HY-107722). This product is intended for research and analytical applications. SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect.
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Tramadol N-oxide
0 ImagesCat. No.: HY-105389CAS No.: 147441-56-3Synonyms: RWJ-38705Tramadol N-oxide (RWJ 38705) is an analgesic. Tramadol N-oxide sproduces dose-related, long-lasting antinociception. Tramadol N-oxide has affinity for μ opioid receptor (Ki = 38.5 μM) and δ, κ receptors (Ki > 100 μM). Tramadol N-oxide can be used for the study of analgesic effect.
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3,4-Difluoro-N-desmethyl U-47700 hydrochloride
0 ImagesCat. No.: HY-158967CAS No.: 2740551-86-23,4-Difluoro-N-desmethyl U-47700 hydrochloride is a utopioid.
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3,4-Difluoro U-49900 hydrochloride
0 ImagesCat. No.: HY-W725198CAS No.: 2743078-88-63,4-Difluoro U-49900 hydrochloride is an opioid.
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Desmethylmoramide
0 ImagesCat. No.: HY-W683876CAS No.: 1767-88-0Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents.
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CHIR 4531
0 ImagesCat. No.: HY-120846CAS No.: 158198-48-2CHIR 4531, a trimer peptide, is a opiate ligand that binds to the mu-opiate receptor with a Ki of 6 nM.
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PZM21 (Standard)
0 ImagesCat. No.: HY-101386RCAS No.: 1997387-43-5PZM21 (Standard) is the analytical standard of PZM21 (HY-101386). This product is intended for research and analytical applications. PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM.
