Salvinorin A propionate
Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A propionate is a non-nitrogenous neoclerodane isolated from Salvia divinorum.
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- CAS No.: 689295-71-4
- Formule: C24H30O8
- Masse moléculaire:446.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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κ Opioid Receptor/KOR |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
140 nM
Compound: 9
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Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
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[PMID: 16033256] |
| CHO | EC50 |
20.4 nM
Compound: 3a
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Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cells
Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cells
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[PMID: 16777411] |
In Vitro
Salvinorin A (0.01-10 pM; pre-30 minues; 24 hours) does not affect the membrane function after 24-h exposure in macrophages[1]. Salvinorin A (0.01-10 pM; pre-30 minues; 18 hours) before LPS stimulation causes a significant and concentrationdependent manner reduction of LPS-stimulated nitrite levels, the IC50 (95% CL) of salvinorin A inhibitory effect was 6.5×10−13M[1]. Salvinorin A (0.01-10 pM; pre-30 minues; 18 hours) incubates 30 min before LPS stimulation, reduces in concentration-dependent manner the LPSinduced iNOS, but not COX-2, hyperexpression, reaching a statistical significance at the 10 pM concentration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 689295-71-4
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Masse moléculaire 446.49
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Formule C24H30O8
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SMILES
C[C@@]([C@@]1([H])CC2)(C[C@@H](C3=COC=C3)OC1=O)[C@](C([C@H]4OC(CC)=O)=O)([H])[C@@]2([C@@H](C4)C(OC)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Butelman ER, et al. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Sep 8; 6:190., et al. [Content Brief]
[2]. John TF, et al. The antinociceptive effect of salvinorin A in mice.Eur J Pharmacol. 2006 Sep 18;545(2-3):129-33. Epub 2006 Jul 4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salvinorin A propionate Related Classifications
HY-137920 Related Classifications
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