Ras Inhibitor

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

Adagrasib (Standard) is the analytical standard of Adagrasib (HY-130149). This product is intended for research and analytical applications. Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction.

ZINC69391 (Standard) is the analytical standard of ZINC69391 (HY-102078). This product is intended for research and analytical applications. ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects.

TH-Z827 diTFA is a selective KRAS^G12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRAS^G12D, but shows no activity against KRAS (WT) and KRAS^G12C. TH-Z827 diTFA blocks the KRAS^G12D-CRAF interaction with a IC₅₀ value of 42 μM. TH-Z827 diTFA can be used for the research of pancreatic cancer.

NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC).