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TAM Receptor Related Products (35)
Related Products (35)
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MerTK-IN-1
0 ImagesCat. No.: HY-169208CAS No.: 3036376-10-7MerTK-IN-1 (compund 31) is a MerTK inhibitor with in vivo target binding ability.
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Bemcentinib-d8
0 ImagesCat. No.: HY-15150SSynonyms: R428-d8; BGB324-d8Bemcentinib-d8 (R428-d8) is the deuterium labeled Bemcentinib (HY-15150). Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer.
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MerTK-IN-2
0 ImagesCat. No.: HY-174160MerTK-IN-2 (compound 15f) is an orally active MerTK inhibitor with an IC50 of 37.5 nM. MerTK-IN-2 can induce apoptosis. MerTK-IN-2 has antitumor activity with IC50 values of 1.79, 18.32, and 2.18 μM for human ovarian cancer cells A2780, breast cancer cells MDA-MB-231, and colon cancer cells HCT116, respectively.
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UNC8969
0 ImagesCat. No.: HY-162406CAS No.: 3036049-17-6UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice.
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(Z)-S49076 hydrochloride
0 ImagesCat. No.: HY-12965BCAS No.: 1265965-19-2(Z)-S49076 hydrochloride is an orally active inhibitor of MET and AXL that blocks the downstream signaling of these receptors both in vitro and in vivo, inhibiting the proliferation and migration of tumor cells and suppressing tumor growth in xenograft models. (Z)-S49076 hydrochloride is capable of overcoming the resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) due to MET amplification in Erlotinib (HY-50896)-resistant cell lines both in vitro and in vivo. (Z)-S49076 hydrochloride can be used for research in non-small cell lung cancer (NSCLC).
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Protein kinase inhibitor 10
0 ImagesCat. No.: HY-169517CAS No.: 871317-00-9Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9, 13.6, and 2.41 μM for TAM receptor, FAK, and KIT, respectively. Protein kinase inhibitor 10 can inhibit abnormal and excessive cell proliferation, showing promise for research in cancer therapy.
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Denfivontinib hydrochloride
0 ImagesCat. No.: HY-W400801CAS No.: 1457983-33-3Synonyms: G-749 hydrochlorideDenfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome.
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Ningetinib Tosylate (Standard)
0 ImagesCat. No.: HY-107145RCAS No.: 1394820-77-9Ningetinib Tosylate (Standard) is the analytical standard of Ningetinib Tosylate (HY-107145). This product is intended for research and analytical applications. Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
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SLC-391
0 ImagesCat. No.: HY-177332CAS No.: 1783825-18-2SLC-391 is an orally active AXL kinase inhibitor with an IC50 of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer.
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CEP-40783 (Standard)
0 ImagesCat. No.: HY-100946RCAS No.: 1437321-24-8Synonyms: RXDX-106 (Standard)
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Ningetinib (Standard)
0 ImagesCat. No.: HY-107145ARCAS No.: 1394820-69-9Ningetinib (Standard) is the analytical standard of Ningetinib (HY-107145A). This product is intended for research and analytical applications. Ningetinib is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
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Gilteritinib hemifumarate (Standard)
0 ImagesSynonyms: ASP2215 hemifumarate (Standard)Gilteritinib hemifumarate (Standard) is the analytical standard of Gilteritinib hemifumarate. This product is intended for research and analytical applications. Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
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ER-851
0 ImagesCat. No.: HY-164382CAS No.: 2685738-33-2ER-851 is a selective AXL inhibitor with oral activity with IC50 of 100 nM. ER-851 has antitumor activity.
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NPS-1034 (Standard)
0 ImagesCat. No.: HY-100509RCAS No.: 1221713-92-3
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