1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
    VEGFR
    c-Met/HGFR
  3. Ningetinib Tosylate

Ningetinib Tosylate 

Cat. No.: HY-107145 Purity: 99.88%
Handling Instructions

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

For research use only. We do not sell to patients.

Ningetinib Tosylate Chemical Structure

Ningetinib Tosylate Chemical Structure

CAS No. : 1394820-77-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 241 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg USD 830 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ningetinib Tosylate:

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Description

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

IC50 & Target

VEGFR2

1.9 nM (IC50)

In Vitro

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. In cell-based functional assays, Ningetinib Tosylate (CT053PTSA) inhibits HGF and VEGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 8.6 and 6.3 nM, respectively[1].

In Vivo

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib Tosylate (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib Tosylate prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.25 mg/mL (11.32 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3721 mL 6.8607 mL 13.7214 mL
5 mM 0.2744 mL 1.3721 mL 2.7443 mL
10 mM 0.1372 mL 0.6861 mL 1.3721 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

728.79

Formula

C₃₈H₃₇FN₄O₈S

CAS No.

1394820-77-9

SMILES

CC1=CC=C(S(=O)(O)=O)C=C1.CC2=C(C(NC3=CC(F)=C(OC4=CC=NC5=C4C=CC(OCC(C)(O)C)=C5)C=C3)=O)C(N(C6=CC=CC=C6)N2C)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ningetinib Tosylate
Cat. No.:
HY-107145
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Ningetinib Tosylate

Cat. No.: HY-107145