1. Signaling Pathways
  2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ALK5 Isoform
  5. ALK5 Inhibitor

ALK5 Inhibitor

ALK5 Inhibitors (19):

Cat. No. Product Name Effect Purity
  • HY-10431
    SB-431542
    Inhibitor 99.89%
    SB-431542 is a TGF-β receptor kinase inhibitor (TRKI).
  • HY-10432
    A 83-01
    Inhibitor 98.83%
    A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.
  • HY-10432A
    A 83-01 sodium
    Inhibitor
    A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.
  • HY-19928
    Vactosertib
    Inhibitor 99.58%
    Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.
  • HY-19928A
    Vactosertib Hydrochloride
    Inhibitor 99.09%
    Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.
  • HY-10431G
    SB-431542 (GMP)
    Inhibitor
    SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines.
  • HY-151289
    ALK5-IN-34
    Inhibitor
    ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor.
  • HY-150169
    THRX-144644
    Inhibitor
    THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM.
  • HY-15897
    LDN-212854
    Inhibitor 99.70%
    LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM).
  • HY-18758
    IN-1130
    Inhibitor 99.79%
    IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation.
  • HY-12953
    R-268712
    Inhibitor 99.78%
    R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM.
  • HY-109179
    Itacnosertib
    Inhibitor 99.77%
    Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871.
  • HY-18766
    EW-7195
    Inhibitor 99.20%
    EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM.
  • HY-151283
    ALK5-IN-33
    Inhibitor
    ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM.
  • HY-123900
    AZ12799734
    Inhibitor
    AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM.
  • HY-151270
    ALK5-IN-25
    Inhibitor
    ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor with an IC50 ≤10 nM.
  • HY-151273
    ALK5-IN-27
    Inhibitor
    ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC50 ≤10 nM.
  • HY-145855
    J-1063
    Inhibitor
    J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM.
  • HY-151275
    ALK5-IN-28
    Inhibitor
    ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling.